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Titolo:
True epithelial hyperplasia in the thymus of early-onset myasthenia gravispatients: implications for immunopathogenesis
Autore:
Roxanis, I; Micklem, K; Willcox, N;
Indirizzi:
John Radcliffe Hosp, Inst Mol Med, Neurosci Grp, Oxford OX3 9DS, England John Radcliffe Hosp Oxford England OX3 9DS Grp, Oxford OX3 9DS, England Univ Oxford, John Radcliffe Hosp, Dept Cellular Sci, Oxford OX3 9DS, England Univ Oxford Oxford England OX3 9DS Cellular Sci, Oxford OX3 9DS, England
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1-2, volume: 112, anno: 2001,
pagine: 163 - 173
SICI:
0165-5728(20010101)112:1-2<163:TEHITT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; ACETYLCHOLINE-RECEPTOR; EXTRACELLULAR-MATRIX; SIGNAL-TRANSDUCTION; ALPHA(6)BETA(4) INTEGRIN; ADHESION RECEPTORS; CELL; EXPRESSION; ACTIVATION; TOLERANCE;
Keywords:
early-onset myasthenia gravis; thymic epithelial cells; epithelial cells; integrins; epidermal growth factor receptor autoimmunization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Willcox, N John Radcliffe Hosp, Inst Mol Med, Neurosci Grp, Oxford OX3 9DS, England John Radcliffe Hosp Oxford England OX3 9DS d OX3 9DS, England
Citazione:
I. Roxanis et al., "True epithelial hyperplasia in the thymus of early-onset myasthenia gravispatients: implications for immunopathogenesis", J NEUROIMM, 112(1-2), 2001, pp. 163-173

Abstract

The early-onset myasthenia gravis (EOMG) thymus shows characteristic medullary epithelial bands (MEB), greatly expanded perivascular infiltrates and fenestrations of the intervening basement membranes. We now compare epithelial expression of epidermal growth factor receptor (EGFR) and many integrins in EOMG and control samples. The main differences are striking/consistentthickening (in MEB) of what is normally a monolayer of perivascular epithelium. with focal protrusion into the infiltrates. This evidently hyperplastic epithelial subpopulation also strongly expresses EGFR and certain integrins. We suggest that its enhanced interactions with the locally increased extracellular matrix protein deposits may play an important role in autosensitization. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:05:39