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Titolo:
The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease
Autore:
Campbell, BCV; McLean, CA; Culvenor, JG; Gai, WP; Blumbergs, PC; Jakala, P; Beyreuther, K; Masters, CL; Li, QX;
Indirizzi:
Univ Melbourne, Dept Pathol, Melbourne, Vic 3010, Australia Univ Melbourne Melbourne Vic Australia 3010 elbourne, Vic 3010, Australia Mental Hlth Res Inst Victoria, Parkville, Vic, Australia Mental Hlth Res Inst Victoria Parkville Vic Australia le, Vic, Australia Flinders Univ S Australia, Ctr Neurosci, Bedford Pk, SA 5042, Australia Flinders Univ S Australia Bedford Pk SA Australia 5042 SA 5042, Australia Flinders Univ S Australia, Dept Physiol, Bedford Pk, SA 5042, Australia Flinders Univ S Australia Bedford Pk SA Australia 5042 SA 5042, Australia Inst Med & Vet Sci, Div Neuropathol, Adelaide, SA 5000, Australia Inst Med& Vet Sci Adelaide SA Australia 5000 delaide, SA 5000, Australia Univ Heidelberg, Ctr Mol Biol, D-6900 Heidelberg, Germany Univ HeidelbergHeidelberg Germany D-6900 ol, D-6900 Heidelberg, Germany Univ Kuopio, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 v Kuopio, FIN-70211 Kuopio, Finland Kuopio Univ Hosp, SF-70210 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland SF-70210 Hosp, SF-70210 Kuopio, Finland
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 1, volume: 76, anno: 2001,
pagine: 87 - 96
SICI:
0022-3042(200101)76:1<87:TSOAIM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; CYTOPLASMIC INCLUSIONS; NACP/ALPHA-SYNUCLEIN; BODY-DISEASE; PROTEIN; ACCUMULATION; AGGREGATION; NEURODEGENERATION; IMMUNOREACTIVITY; PATHOGENESIS;
Keywords:
alpha-synuclein; dementia with Lewy bodies; multiple system atrophy; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: McLean, CA Univ Melbourne, Dept Pathol, Melbourne, Vic 3010, Australia Univ Melbourne Melbourne Vic Australia 3010 ic 3010, Australia
Citazione:
B.C.V. Campbell et al., "The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease", J NEUROCHEM, 76(1), 2001, pp. 87-96

Abstract

Intracellular inclusions containing alpha -synuclein (alpha SN) are pathognomonic features of several neurodegenerative disorders. Inclusions occur in oligodendrocytes in multiple system atrophy (MSA) and in neurons in dementia with Lewy bodies (DLB) and Parkinson's disease (PD). In order to identify disease-associated changes of aSN, this study compared the levels, solubility and molecular weight species of aSN in brain homogenates from MSA, DLB, PD and normal aged controls. In DLB and PD, substantial amounts of detergent-soluble and detergent-insoluble alpha SN were detected compared with controls in grey matter homogenate. Compared with controls, MSA cases had significantly higher levels of alpha SN in the detergent-soluble fraction of brain samples from pens and white matter but detergent-insoluble alpha SN was not detected. There was an inverse correlation between buffered saline-soluble and detergent-soluble levels of alpha SN in individual MSA cases suggesting a transition towards insolubility in disease. The differences in solubility of alpha SN between grey and white matter in disease may result from different processing of alpha SN in neurons compared with oligodendrocytes. Highly insoluble alpha SN is not involved in the pathogenesis of MSA. It is therefore possible that buffered saline-soluble or detergent-soluble forms of alpha SN are involved in the pathogenesis of other alpha SN-relateddiseases.

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Documento generato il 31/03/20 alle ore 04:40:26