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Titolo:
Absence of any significant effects of circadian blood pressure variations on carotid artery elastic properties in essential hypertensive subjects
Autore:
Tsioufis, C; Stefanadis, C; Antoniadis, D; Kallikazaros, I; Zambaras, P; Pitsavos, C; Tsiamis, E; Toutouzas, P;
Indirizzi:
Univ Athens, Hippokratio Gen Hosp, Dept Cardiol, Athens, Greece Univ Athens Athens Greece kratio Gen Hosp, Dept Cardiol, Athens, Greece
Titolo Testata:
JOURNAL OF HUMAN HYPERTENSION
fascicolo: 12, volume: 14, anno: 2000,
pagine: 813 - 818
SICI:
0950-9240(200012)14:12<813:AOASEO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR HYPERTROPHY; TO-MODERATE HYPERTENSION; CARDIOVASCULAR RISK; DISTENSIBILITY; DIPPERS; DISEASE; REPRODUCIBILITY; ABNORMALITIES; NONDIPPERS; DAMAGE;
Keywords:
dippers and non-dippers; carotid artery elastic properties; blood pressure variability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Tsioufis, C 4 Athanasiou Diakou St, Melissia 15127, Greece 4 Athanasiou Diakou St Melissia Greece 15127 a 15127, Greece
Citazione:
C. Tsioufis et al., "Absence of any significant effects of circadian blood pressure variations on carotid artery elastic properties in essential hypertensive subjects", J HUM HYPER, 14(12), 2000, pp. 813-818

Abstract

We sought in this study to examine the effects of diurnal blood pressure variations upon common carotid artery (CCA) elasticity in selected subjects with uncomplicated moderate essential hypertension. Towards this end, 174 non-smoker subjects with stage I-II essential hypertension and without diabetes mellitus, left ventricular hypertrophy and carotid atherosclerosis, were classified as dippers and non-dippers according to the diurnal variation of >10% between mean daytime and night-time systolic and diastolic blood pressure (BP) in 24-h noninvasive ambulatory BP monitoring. CCA distensibility was derived by a combination of surface ultrasonographic data and simultaneous BP measurements at the brachial artery, The dippers and non-dippers were similar with respect to demographic characteristics. Non-dippers had significantly greater office systolic BP, 24-h systolic BP and ambulatory pulse pressure (PP) and significantly less (daytime-night-time) systolic and diastolic BP fall (by 16 mm Hg and 11 mm Hg respectively, P < 0.0001) compared to dippers. CCA distensibility was significantly reduced in non-dippers compared to dippers (by 0.89 dyne(-1)/cm(2)/10(-6), P < 0.05). Multiple linear regression analysis identified patient age and ambulatory PP as significant predictors of the CCA elasticity index. When patient age, 24-h systolic and diastolic BP were used as covariates in an analysis of covariance, the difference of CCA elasticity between dippers and non-dippers ceased to reach statistical significance. In contrast, when patient age, ambulatory PP,systolic (daytime-night-time) BP fall and diastolic (daytime-night-time) BP fall were used as covariates, the difference of CCA distensibility between dippers and non-dippers continued to be statistically significant. In conclusion, the excessive impairment of CCA elastic properties in non-dippers compared to dippers hypertensive seems to be ascribed to the increased of total 24-h haemodynamic load and not to the circadian pattern of BP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:31:05