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Titolo:
AGE AND SEX-RELATED DIFFERENCES IN SERUM LEVELS OF UNCONJUGATED DEHYDROEPIANDROSTERONE AND ITS SULFATE IN NORMAL SUBJECTS
Autore:
SULCOVA J; HILL M; HAMPL R; STARKA L;
Indirizzi:
INST ENDOCRINOL,NARODNI 8 PRAGUE 11694 1 CZECH REPUBLIC
Titolo Testata:
Journal of Endocrinology
fascicolo: 1, volume: 154, anno: 1997,
pagine: 57 - 62
SICI:
0022-0795(1997)154:1<57:AASDIS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA DEHYDROEPIANDROSTERONE; DEHYDROISOANDROSTERONE SULFATE; TESTOSTERONE; PUBERTY; ADULTHOOD; BIRTH; FSH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
J. Sulcova et al., "AGE AND SEX-RELATED DIFFERENCES IN SERUM LEVELS OF UNCONJUGATED DEHYDROEPIANDROSTERONE AND ITS SULFATE IN NORMAL SUBJECTS", Journal of Endocrinology, 154(1), 1997, pp. 57-62

Abstract

Dehydroepiandrosterone sulphate (DHEAS) and unconjugated dehydroepiandrosterone (DHEA) have been determined in the blood serum of normal subjects of both sexes from 1 month to 100 years of age. In total, 92 girls, 49 boys, 211 women and 110 men were investigated. The effects of age and sex on the levels of the hormones were measured. DHEAS levels declined rapidly during the first year of life and were maintained at a minimum level for 5 years. They increased significantly from 6 to 7 years of age and reached maximum levels in women at about 24 years andin men at about 30 years of age. They then declined rapidly in both sexes but the fall which occurred after 50 and 60 years of age respectively was only moderate. Age-related unconjugated DHEA levels were different. After the first month of life DHEA levels were relatively high and declined more slowly. The minimum level was observed in girls between 5 and 7 years and in boys between 5 and 9 years of age. A significant rise then began and levels reached a maximum in women as well as in men at about 20 years of age. In men levels then declined up to the age of 80. In women the DHEA levels declined during the next 15 years and from approximately 36 years of age they again rose significantly up to a second peak. A mild but significant decline then resumed. Therewas a difference in the levels of DHEA and DHEAS depending on sex. Unlike DHEAS, unconjugated DHEA was higher in women than in men. However, this difference was significant only in some age groups: during puberty (between 11 and 15 years of age), in the premenopausal period (between 36 and 45 years oi age) and in the older group (after 60 years ofage). Age- and sex-related dependencies were different between DHEAS and DHEA. They indicate the possible variable secretion and dynamics of their (inter)conversion. We have concluded that DHEA measurements cannot be a substitute for DHEAS and vice versa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 12:22:28