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Titolo:
Comparison of the timing of acute blood-brain barrier breakdown to rabbit immunoglobulin G in the cerebellum and spinal cord of mice with experimental autoimmune encephalomyelitis
Autore:
Tonra, JR; Reiseter, BS; Kolbeck, R; Nagashima, K; Robertson, R; Keyt, B; Lindsay, RM;
Indirizzi:
Millennium Pharmaceut Inc, Cambridge, MA 02139 USA Millennium Pharmaceut Inc Cambridge MA USA 02139 Cambridge, MA 02139 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 1, volume: 430, anno: 2001,
pagine: 131 - 144
SICI:
0021-9967(20010129)430:1<131:COTTOA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; VASCULAR-PERMEABILITY CHANGES; PLASMA-PROTEIN EXTRAVASATION; MYELIN PROTEOLIPID PROTEIN; MULTIPLE-SCLEROSIS; BORDETELLA-PERTUSSIS; RAT; DISRUPTION; LESIONS;
Keywords:
multiple sclerosis; experimental autoimmune encephalomyelitis; pathogenesis; extravasation; antibody;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Tonra, JR Millennium Pharmaceut Inc, 640 Mem Dr, Cambridge, MA 02139 USA Millennium Pharmaceut Inc 640 Mem Dr Cambridge MA USA 02139 USA
Citazione:
J.R. Tonra et al., "Comparison of the timing of acute blood-brain barrier breakdown to rabbit immunoglobulin G in the cerebellum and spinal cord of mice with experimental autoimmune encephalomyelitis", J COMP NEUR, 430(1), 2001, pp. 131-144

Abstract

Experimental autoimmune encephalomyelitis (EAE) is an animal model for human multiple sclerosis (MS). Similar to MS patients, EAE animals can exhibitchronic or relapsing, remitting paralysis; leukocyte infiltration of the central nervous system (CNS); and breakdown of the blood-brain barrier (BBB), allowing access to serum components. EAE pathology in rodents is generally thought to progress from the spinal cord to the more rostral brain. This common notion is based on numerous reports on the severity and progression of cellular infiltration and BBB breakdown during the course of disease. Westudied opening of the BBB in EAE mice immunized to the proteolipid protein (PLP) peptide, PLP 139-151, with or without the use of pertussis toxin. Peripherally injected rabbit immunoglobulin G showed significant penetrationthrough a compromised BBB in EAE mice and was observed throughout the parenchyma as well as intracellularly in multiple neuronal types. Results demonstrate the novel finding that the cerebellar BBB is dramatically and briefly comprised, even before breakdown of the BBB in the thoracolumbar spinal cord and prior to symptomatic disease. The demonstration of susceptibility in the cerebellum provides an important target for studying the factors predisposing certain CNS regions to autoimmune-related compromise of the BBB, such as MS. J. Comp. Neurol. 430:131-144, 2001. (C) Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:28:29