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Titolo:
Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophages
Autore:
Shimaoka, T; Kume, N; Minami, M; Hayashida, K; Kataoka, H; Kita, T; Yonehara, S;
Indirizzi:
Kyoto Univ, Inst Virus Res, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Virus Res, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 d Sch Med, Sakyo Ku, Kyoto 6068507, Japan
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 52, volume: 275, anno: 2000,
pagine: 40663 - 40666
SICI:
0021-9258(200012)275:52<40663:MCOANS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ATHEROSCLEROTIC LESIONS; ENDOTHELIAL RECEPTOR; CELLS; EXPRESSION; PROTEIN; CD36;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Yonehara, S Kyoto Univ, Inst Virus Res, Sakyo Ku, Shogoin Kawahara Cho 53,Kyoto 6068507, Japan Kyoto Univ Shogoin Kawahara Cho 53 Kyoto Japan 6068507 Japan
Citazione:
T. Shimaoka et al., "Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophages", J BIOL CHEM, 275(52), 2000, pp. 40663-40666

Abstract

Receptor-mediated endocytosis of oxidized low density lipoprotein (OxLDL) by macrophages has been implicated in foam cell transformation in the process of atherogenesis. Although several scavenger receptor molecules, including class A scavenger receptors and CD36, have been identified as OxLDL receptors on macrophages, additional molecules on macrophages may also be involved in the recognition of OxLDL. From a cDNA library of phorbol Ig-myristate Is-acetate-stimulated THP-1 cells, we isolated a cDNA encoding a novel protein designated SR-PSOX (scavenger receptor that binds Ehosphatidylserine and oxidized lipoprotein), which acts as a receptor for OxLDL, SR-PSOX was a type I membrane protein consisting of 254 amino acids, expression of which was shown on human and murine macrophages with a molecular mass of 30 kDa, SR-PSOX could specifically bind with high affinity, internalize, and degrade OxLDL. The recognition of OxLDL was blocked by polyinosinic acid and dextran sulfate but not by acetylated low density lipoprotein. Taken together, SR-PSOX is a novel class of molecule belonging to the scavenger receptor family, which may play important roles in pathophysiology including atherogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:48:14