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Titolo:
Effects of low mercury vapour exposure on the thyroid function in chloralkali workers
Autore:
Ellingsen, DG; Efskind, J; Haug, E; Thomassen, Y; Martinsen, I; Gaarder, PI;
Indirizzi:
Natl Inst Occupat Hlth, N-0033 Oslo, Norway Natl Inst Occupat Hlth Oslo Norway N-0033 upat Hlth, N-0033 Oslo, Norway Borregaard Ind Ltd, Dept Hlth, N-1700 Sarpsborg, Norway Borregaard Ind Ltd Sarpsborg Norway N-1700 lth, N-1700 Sarpsborg, Norway Aker Univ Hosp, Hormone Lab, N-0514 Oslo, Norway Aker Univ Hosp Oslo Norway N-0514 Hosp, Hormone Lab, N-0514 Oslo, Norway Nycomed Imaging AS, N-4220 Oslo, Norway Nycomed Imaging AS Oslo Norway N-4220 ed Imaging AS, N-4220 Oslo, Norway Univ Oslo, Ullevaal Hosp, Dept Immunol & Transfus Med, N-0407 Oslo, NorwayUniv Oslo Oslo Norway N-0407 Immunol & Transfus Med, N-0407 Oslo, Norway
Titolo Testata:
JOURNAL OF APPLIED TOXICOLOGY
fascicolo: 6, volume: 20, anno: 2000,
pagine: 483 - 489
SICI:
0260-437X(200011/12)20:6<483:EOLMVE>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; FACTOR-ALPHA-CACHECTIN; INORGANIC MERCURY; IMMUNE-SYSTEM; HORMONE DEIODINASES; ENDOCRINE FUNCTION; MASS-SPECTROMETRY; PITUITARY; PEROXIDASE; METABOLISM;
Keywords:
mercury vapour; reverse triiodothyronine; ratio free T-4/free T-3; tumour necrosis factor-alpha; urinary iodine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ellingsen, DG Natl Inst Occupat Hlth, POB 8149 Dep, N-0033 Oslo, Norway Natl Inst Occupat Hlth POB 8149 Dep Oslo Norway N-0033 rway
Citazione:
D.G. Ellingsen et al., "Effects of low mercury vapour exposure on the thyroid function in chloralkali workers", J APPL TOX, 20(6), 2000, pp. 483-489

Abstract

Forty-seven chloralkali workers exposed to mercury vapour for an average of 13.3 years were compared with 47 referents matched for age in a cross-sectional study of thyroid function. The mean urinary mercury concentration inthe exposed workers was low compared with other studies of chloralkali workers: 5.9 nmol mmol(-1) creatinine (range 1.1-16.8) vs 1.3 nmol mmol(-1) creatinine (range 0.2-5.0) in the reference group. The median serum concentration of reverse triiodothyronine (rT(3)) was statistically significantly higher in the exposed subjects compared with the referents (268 pmol l(-1) and range 161-422 vs 240 pmol l(-1) and range 129-352; P=0.009), The difference between the exposed subjects and the referents was most pronounced in the highest exposed subgroups. The free thyroxine (T-4)/free T-3 ratio was also higher in the highest exposed subgroups compared with the referents. Themedian serum concentration of tumour necrosis factor alpha (TNF-alpha) waslower in the exposed subjects (7.3 pg ml(-1) and range 4.4-69.7 vs 8.0 pg ml(-1) and range 6.0-34.6; P = 0.004), Exposed subjects with the lowest urinary iodine (<67.8 nmol mmol(-1) Cr) had higher serum concentrations of reverse T-3 and a higher free T-4/free T-3 ratio than the other subjects, suggesting that a low concentration of iodine in urine may be a risk factor forincreased serum concentrations of reverse T-3 and the free T-4/free T-3 ratio in subjects exposed occupationally to mercury vapour. The study could indicate a slight effect of low mercury vapour exposure on the function of the enzyme type I iodothyronine deiodinase, possibly modified by comparatively low urinary iodine concentrations. Copyright (C) 2000 John Wiley & Sons,Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:59:10