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Titolo:
Macular pigment in donor eyes with and without AMD: A case-control study
Autore:
Bone, RA; Landrum, JT; Mayne, ST; Gomez, CM; Tibor, SE; Twaroska, EE;
Indirizzi:
Florida Int Univ, Dept Phys, Miami, FL 33199 USA Florida Int Univ Miami FL USA 33199 Univ, Dept Phys, Miami, FL 33199 USA Florida Int Univ, Dept Chem, Miami, FL 33199 USA Florida Int Univ Miami FL USA 33199 Univ, Dept Chem, Miami, FL 33199 USA Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 iol & Publ Hlth, New Haven, CT 06510 USA
Titolo Testata:
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
fascicolo: 1, volume: 42, anno: 2001,
pagine: 235 - 240
SICI:
0146-0404(200101)42:1<235:MPIDEW>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGE-RELATED MACULOPATHY; BEAVER DAM EYE; GEOGRAPHIC ATROPHY; OPTICAL-DENSITY; DEGENERATION; CAROTENOIDS; SMOKING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Bone, RA Florida Int Univ, Dept Phys, 11200 SW 8th St, Miami, FL 33199 USAFlorida Int Univ 11200 SW 8th St Miami FL USA 33199 FL 33199 USA
Citazione:
R.A. Bone et al., "Macular pigment in donor eyes with and without AMD: A case-control study", INV OPHTH V, 42(1), 2001, pp. 235-240

Abstract

PURPOSE. To determine whether there is an association between the density of macular pigment in the human retina and the risk of age-related macular degeneration (AMD). METHODS. Retinas from 56 donors with AMD and 56 controls were cut into three concentric regions centered on the fovea. The inner, medial, and outer regions covered the visual angles 0 degrees to 5 degrees, 5 degrees to 19 degrees, and 19 degrees to 38 degrees, respectively. The amounts of lutein (L) and zeaxanthin (Z) extracted from each tissue sample were determined by high-performance liquid chromatography. RESULTS. L and Z levels in all three concentric regions were less, on average, for the AMD donors than for the controls. The differences decreased inmagnitude from the inner to medial to outer regions. The lower levels found in the inner and medial regions for AMD donors may be attributable, in part, to the disease. Comparisons between AMD donors and controls using the outer (peripheral) region were considered more reliable. For this region, logistic regression analysis indicated that those in the highest quartile of L and Z level had an 82% lower risk for AMD compared with those in the lowest quartile (age- and sex-adjusted odds ratio = 0.18, 95% confidence interval = 0.05-0.64). CONCLUSIONS. The results are consistent with a theoretical model that proposes an inverse association between risk of AMD and the amounts of L and Z in the retina. The results are inconsistent with a model that attributes a loss of L and Z in the retina to the destructive effects of AMD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 19:50:46