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Titolo:
Effect of methylprednisolone on the kinetics of cytokines and liver function of regenerating liver in rats
Autore:
Fujioka, T; Murakami, M; Niiya, T; Aoki, T; Murai, N; Enami, Y; Kusano, M;
Indirizzi:
Showa Univ, Sch Med, Dept Surg 2, Shinagawa Ku, Tokyo 1428666, Japan ShowaUniv Tokyo Japan 1428666 urg 2, Shinagawa Ku, Tokyo 1428666, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 1, volume: 19, anno: 2001,
pagine: 60 - 73
SICI:
1386-6346(200101)19:1<60:EOMOTK>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; ACUTE-PHASE RESPONSE; PARTIAL-HEPATECTOMY; MAJOR HEPATECTOMY; FACTOR RECEPTOR; FACTOR-ALPHA; INTERLEUKIN-6; MICE; PROLIFERATION; ENDOTOXEMIA;
Keywords:
methylprednisolone (MDS); interleukin-6 (IL-6); tumor necrosis factor-alpha (TNF alpha); liver regeneration; anti-Ki-67 monoclonal antibody (MIB-5); 5-bromo-2-deoxyuridinc (BrdU);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Fujioka, T Showa Univ, Sch Med, Dept Surg 2, Shinagawa Ku, 1-5-8 Hatanodai, Tokyo 1428666, Japan Showa Univ 1-5-8 Hatanodai Tokyo Japan 1428666 1428666, Japan
Citazione:
T. Fujioka et al., "Effect of methylprednisolone on the kinetics of cytokines and liver function of regenerating liver in rats", HEPATOL RES, 19(1), 2001, pp. 60-73

Abstract

The participation of cytokines in the early stage mechanism of hepatocyte proliferation has already attracted attention. We investigated the effect of methylprednisolone (MDS). which inhibits the inflammatory response, givenbefore and after a 70% partial hepatectomy in rats on the kinetics of tumor necrosis factor-alpha and Interleukin-6, liver cell function and the rateof liver regeneration. Serum Interleukin-6 levels of the MDS groups were significantly lower than those of the control group. Serum alanine aminotransferase, aspartate aminotransferase and hyaluronic acid levels were also significantly decreased, however, the serum albumin level showed high values in the MDS groups. In the MDS groups, MIB-5 labeling indices, a novel antibody reactive with the equivalent Ki-67 protein, which detects immunohistochemically all active parts of the cell cycle in the rat liver, were more pronounced than in the control group at an earlier time. However, in regard to5-bromo-2-deoxyuridine (BrdU), there were no significant differences amongthe three groups. There were no differences in residual liver weight/body weight between the three groups after 336 h. In our study, MDS administration before or after a 70% partial hepatectomy decreased serum Interleukin-6 levels, and inhibited hepatic dysfunction. Therefore, we considered that beneficial effects of physiological doses of MDS in the peri-operative periodshould be confirmed in humans. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:59:23