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Titolo:
Efficacy of IFN therapy based on duration period of negative HCV-RNA during IFN administration
Autore:
Arase, Y; Ikeda, K; Chayama, K; Murashima, N; Tsubota, A; Suzuki, Y; Saitoh, S; Kobayashi, M; Kobayashi, M; Suzuki, F; Kumada, H;
Indirizzi:
Toranomon Gen Hosp, Dept Gastroenterol, Minato Ku, Tokyo 105, Japan Toranomon Gen Hosp Tokyo Japan 105 oenterol, Minato Ku, Tokyo 105, Japan Toranomon Gen Hosp, Hepat Res Unit, Minato Ku, Tokyo 105, Japan Toranomon Gen Hosp Tokyo Japan 105 Res Unit, Minato Ku, Tokyo 105, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 1, volume: 19, anno: 2001,
pagine: 22 - 30
SICI:
1386-6346(200101)19:1<22:EOITBO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC HEPATITIS-C; POLYMERASE CHAIN-REACTION; RANDOMIZED CONTROLLED TRIAL; INTERFERON-ALPHA THERAPY; HEPATOCELLULAR-CARCINOMA; VIRUS GENOTYPES; DISEASE; SERUM; CLASSIFICATION; PROGRESSION;
Keywords:
chronic hepatitis C; prolonged interferon therapy; HCV-RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Arase, Y Toranomon Gen Hosp, Dept Gastroenterol, Minato Ku, 2-2-2 Toranomon, Tokyo 105, Japan Toranomon Gen Hosp 2-2-2 Toranomon Tokyo Japan 105 yo 105, Japan
Citazione:
Y. Arase et al., "Efficacy of IFN therapy based on duration period of negative HCV-RNA during IFN administration", HEPATOL RES, 19(1), 2001, pp. 22-30

Abstract

We assessed the relationship between the duration period of negative hepatitis C virus (HCV)-RNA during interferon (IFN) therapy and the efficacy after prolonged IFN therapy in patients with HCV-genotype Ib and high virus load of more than 1 mega equivalents/ml (Meq/ml) retrospectively. A total of 100 patients who had HCV-genotype Ib and a high virus load of more than 1 Meq/ml and were treated with natural IFN-alpha for more than 1? months were enrolled in this trial. These patients were given 6 MU of IFN daily for 8 weeks, followed by three times weekly for another more than 44 weeks. The HCV-RNA pattern during IFN therapy according to negative or positive of the serum HCV-RNA by reverse transcription nested polymerase chain reaction (RT-nested PCR) from 2 months after the initiation of IFN to the termination ofIFN were classified as follows: group 1: constant negative HCV-RNA (n = 41cases), group 2. constant positive MCV-RNA (n = 35 cases), group 3: HCV-RNA pattern except for group 1 or group 2 (il = 24 cases). A complete response (CR) was defined as negative HCV-RNA by RT-nested PCR at two points, 3 and 6 months after the completion of IFN therapy. CR rate was 58.5% (24 cases) in group 1, but CR rate in group 2 or group 3 was 0%. In group 1, the CR rate was 100%(10/10) in patients with negative HCV-RNA constantly for period of more than 24 months during IFN therapy. On the other. hand, all patients who had positive HCV-RNA 2 months after the initiation of IFN did not get CR. In conclusion, it seems to us that the attainment of constantly negative I-ICV-RNA for the period of more than 24 months during IFN therapy is highly related to CR. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:53:20