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Titolo:
Increased serum concentrations of advanced glycation end products: a marker of coronary artery disease activity in type 2 diabetic patients
Autore:
Kiuchi, K; Nejima, J; Takano, T; Ohta, M; Hashimoto, H;
Indirizzi:
Nippon Med Sch, Intens & Coronary Care Unit, Tokyo 1138603, Japan Nippon Med Sch Tokyo Japan 1138603 onary Care Unit, Tokyo 1138603, Japan Nippon Med Sch, Dept Internal Med 1, Tokyo 1138603, Japan Nippon Med Sch Tokyo Japan 1138603 Internal Med 1, Tokyo 1138603, Japan
Titolo Testata:
HEART
fascicolo: 1, volume: 85, anno: 2001,
pagine: 87 - 91
SICI:
1355-6037(200101)85:1<87:ISCOAG>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADVANCED GLYCOSYLATION; COMPLICATIONS; CHOLESTEROL; NEPHROPATHY; RECEPTOR; TISSUE;
Keywords:
advanced glycation end products; non-insulin dependent diabetes; coronary artery disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Kiuchi, K Nippon Med Sch, Intens & Coronary Care Unit, Tokyo 1138603, Japan Nippon Med Sch Tokyo Japan 1138603 Unit, Tokyo 1138603, Japan
Citazione:
K. Kiuchi et al., "Increased serum concentrations of advanced glycation end products: a marker of coronary artery disease activity in type 2 diabetic patients", HEART, 85(1), 2001, pp. 87-91

Abstract

Objective-To assess whether the concentrations of serum advanced glycationend products (AGE) in diabetic patients with obstructive coronary artery disease differ from those in type 2 diabetic patients without obstructive coronary artery disease. Design-Serum AGE concentrations were measured in type 2 diabetic patients and in non-diabetic patients, both with and without obstructive coronary artery disease, and the relation between these values and coronary disease severity was evaluated. Results-Mean (SD) serum AGE concentrations were higher (p < 0.0125) in type 2 diabetic patients with obstructive coronary artery disease (5.5 (2.5) mU/ml, n = 30) than in patients without obstructive coronary artery disease (2.8 (0.5) mU/ml, n = 12), and higher than in non diabetic patients with (3.4 (1.0) mU/ml, n = 28) and without (3.2 (0.4) mU/ml, n = 13) obstructive coronary artery disease. Serum AGE was associated with the degree of coronary arteriosclerosis in type 2 diabetic patients with obstructive coronary artery disease (single vessel: n = 13, 3.4 (0.9) mU/m; two vessel: n = 6, 5.7(1.6) mU/m; three vessel: n = 11, 7.2 (2.5) mU/ml). Serum AGE was positively correlated with serum mean four year HbA(1C) (r = 0.46, p < 0.01), but not with recent serum HbA(1C) (r = 0.24). The four groups did not differ in the other coronary risk factors. Conclusions-Serum AGE concentrations may be associated with long term poorglycaemic control and reflect the severity of coronary arteriosclerosis intype 2 diabetic patients.

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Documento generato il 19/09/20 alle ore 18:08:19