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Titolo:
Success and safety of sputum induction in the clinical setting
Autore:
Vlachos-Mayer, H; Leigh, R; Sharon, RF; Hussack, P; Hargreave, FE;
Indirizzi:
St Josephs Hosp, Firestone Reg Chest & Allergy Unit, Asthma Res Grp, Hamilton, ON L8N 4A6, Canada St Josephs Hosp Hamilton ON Canada L8N 4A6 , Hamilton, ON L8N 4A6, Canada McMaster Univ, Hamilton, ON, Canada McMaster Univ Hamilton ON CanadaMcMaster Univ, Hamilton, ON, Canada
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 5, volume: 16, anno: 2000,
pagine: 997 - 1000
SICI:
0903-1936(200011)16:5<997:SASOSI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIRWAY INFLAMMATION; ASTHMA; PREDNISONE; INDEXES; CELL;
Keywords:
asthma; chronic airflow limitation; sputum induction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Hargreave, FE St Josephs Hosp, Firestone Reg Chest & Allergy Unit, Asthma Res Grp, 50 Charlton Ave E, Hamilton, ON L8N 4A6, Canada St Josephs Hosp 50Charlton Ave E Hamilton ON Canada L8N 4A6
Citazione:
H. Vlachos-Mayer et al., "Success and safety of sputum induction in the clinical setting", EUR RESP J, 16(5), 2000, pp. 997-1000

Abstract

It has previously been reported that sputum induction is successful and safe in the clinical research setting. The authors examined the success and safety of sputum induction in routine clinical practice in patients with asthma or chronic airflow limitation of varying severity. Records of 304 patients with asthma and 25 with smoking related chronic airflow limitation were examined retrospectively. All had sputum induced as part of their routine clinical evaluation. When the baseline post salbutamolforced expiratory volume in one second (FEV1) was greater than or equal to70% predicted, the inductions consisted of inhalation of an aerosol of 3%,4% and 5% saline, each given for 7 min. If the FEV1 was <70%, or there were other reasons for concern, the inductions were initiated with normal saline for shorter periods. Inhalations were discontinued when sputum was obtained or when there was a fall in FEV1 <greater than or equal to>20%. Successwas identified by obtaining nonsquamous total and differential cell countscontaining macrophages, and safety by the fall in FEV1. The overall success was 93%. The procedure was safe even amongst patients with an FEV1 of <60% and <1 L. Of 77 patients with an FEV1 between 40-59%, 8% fell by greater than or equal to 20% and of 35 patients with an FEV1 <40%, 6% fell by 20%. Carefully standardized sputum induction can be successful and safe in patients with asthma or chronic airflow limitation in clinical practice, even when moderate or severe airflow limitation is present.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:37:28