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Titolo:
Comparative study of single-injection, single-acquisition Tc-99m-MIBI gated SPET and stress-rest perfusion SPET for the evaluation of myocardial viability after bypass surgery in coronary artery disease
Autore:
Yoon, SN; Lee, DS; Chung, JK; Lee, MC;
Indirizzi:
Ajou Univ, Sch Med, Dept Nucl Med, Suwon 441749, South Korea Ajou Univ Suwon South Korea 441749 t Nucl Med, Suwon 441749, South Korea Seoul Natl Univ, Coll Med, Dept Nucl Med, Seoul 110744, South Korea Seoul Natl Univ Seoul South Korea 110744 Med, Seoul 110744, South Korea
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 12, volume: 27, anno: 2000,
pagine: 1747 - 1753
SICI:
0340-6997(200012)27:12<1747:CSOSST>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; SESTAMIBI SPECT; SEPARATE;
Keywords:
gated myocardial SPET; bypass surgery; myocardial viability; wall thickening; reversibility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Yoon, SN Ajou Univ, Sch Med, Dept Nucl Med, Suwon 441749, South Korea AjouUniv Suwon South Korea 441749 d, Suwon 441749, South Korea
Citazione:
S.N. Yoon et al., "Comparative study of single-injection, single-acquisition Tc-99m-MIBI gated SPET and stress-rest perfusion SPET for the evaluation of myocardial viability after bypass surgery in coronary artery disease", EUR J NUCL, 27(12), 2000, pp. 1747-1753

Abstract

In patients without previous myocardial infarction, the single-injection stress perfusion/rest function (SISPRF) approach using stress technetium-99mmethoxyisobutylisonitrile (MIBI) gated single-photon emission tomography (SPET) can substitute for conventional stress-rest myocardial perfusion imaging for the assessment of myocardial viability. This study compared pre-operative single-injection, single-acquisition Tc-99m-MIBI gated SPET and conventional stress-rest imaging for the prediction of myocardial viability in patients who underwent coronary artery bypass surgery (CABG). Rest thallium-201 SPET followed by stress 99mTc-MIBI gated SPET was performed in 20 patients (nine with previous myocardial infarction (MI) and 11 without previousMI). The study was performed before and 3 months after CABG, and viabilityassessment was validated by wall motion improvement after CABG. A four-point scoring system (0-3 for normal to absent tracer uptake) for 17 segments of the left ventricular myocardium was used for the assessment of stress and rest uptake. Wall motion, wail thickening and perfusion status were analysed by semi-quantitative visual assessment. On gated SPET, perfusion defectreversibility was considered present when a definite perfusion defect was observed and wall motion or thickening was normal or showed only a mild decrease. In patients with a previous MI, the left ventricular ejection fraction improved significantly after CABG (46% +/- 7% vs 42% +/- 11% before CABG, P < 0.05). In patients without previous MI, the ejection fraction improved significantly after CABG (50 <plus/minus> 12% vs 44% +/- 16% before CABG,P < 0.05), In patients with previous MI, positive predictive values using the stress-rest reversibility and SISPRF approaches were 91% and 90%, respectively, and corresponding negative predictive values were 25% and 18%. In patients without previous MI, positive predictive values using the stress-rest and SISPRF approaches were 70% and 61%, respectively, and correspondingnegative predictive values were 63% and 14%. It is concluded that SISPRF SPET study is of similar value to conventional stress-rest perfusion study in predicting wall motion improvement in patients with a previous MI, but that it is of limited value in predicting the myocardial viability of patients without previous MI, owing to a lower predictive value.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:58:41