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Titolo:
Nerve growth factor expression in parasympathetic neurons: regulation by sympathetic innervation
Autore:
Hasan, W; Smith, PG;
Indirizzi:
Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66160 USA Univ Kansas Kansas City KS USA 66160 t Physiol, Kansas City, KS 66160 USA Univ Kansas, Med Ctr, RL Smith Ment Retardat Res Ctr, Kansas City, KS 66160 USA Univ Kansas Kansas City KS USA 66160 t Res Ctr, Kansas City, KS 66160 USA
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 12, volume: 12, anno: 2000,
pagine: 4391 - 4397
SICI:
0953-816X(200012)12:12<4391:NGFEIP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR MESSENGER-RNA; RETROGRADE AXONAL-TRANSPORT; GUINEA-PIG TRACHEA; SENSORY NEURONS; URINARY-BLADDER; LOCAL-CONTROL; ADRENERGIC TRANSMISSION; FACTOR RECEPTOR; SMOOTH-MUSCLE; FACTOR NGF;
Keywords:
pterygopalatine ganglion; sympathectomy; decentralization; rat; in situ hybridization; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, PG Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, 3901 Rainbow Blvd, Kansas City, KS 66160 USA Univ Kansas 3901 Rainbow Blvd Kansas City KS USA 66160 66160 USA
Citazione:
W. Hasan e P.G. Smith, "Nerve growth factor expression in parasympathetic neurons: regulation by sympathetic innervation", EUR J NEURO, 12(12), 2000, pp. 4391-4397

Abstract

Interactions between sympathetic and parasympathetic nerves are important in regulating visceral target function. Sympathetic nerves are closely apposed to, and form functional synapses with, parasympathetic axons in many effector organs. The molecular mechanisms responsible for these structural and functional interactions are unknown. We explored the possibility that Nerve Growth Factor (NGF) synthesis by parasympathetic neurons provides a mechanism by which sympathetic-parasympathetic interactions are established. Parasympathetic pterygopalatine ganglia NGF-gene expression was examined by in situ hybridization and protein content assessed by immunohistochemistry. Under control conditions, NGF mRNA was present in approximate to 60% and NGF protein was in 40% of pterygopalatine parasympathetic neurons. Peripheralparasympathetic axons identified by vesicular acetylcholine transporter-immunoreactivity also displayed NGF immunoreactivity. To determine if sympathetic innervation regulates parasympathetic NGF expression, the ipsilateral superior cervical ganglion was excised. Thirty days postsympathectomy, the numbers of NGF mRNA-positive neurons were decreased to 38% and NGF immunoreactive neurons to 15%. This reduction was due to a loss of sympathetic nerve impulse activity, as similar reductions were achieved when superior cervical ganglia were deprived of preganglionic afferent input for 40 days. These findings provide evidence that normally NGF is synthesized by parasympathetic neurons and transported anterogradely to fibre terminals, where it maybe available to sympathetic axons. Parasympathetic NGF expression, in turn, is augmented by impulse activity within (and presumably transmitter release from) sympathetic axons. It is suggested that parasympathetic NGF synthesis and its modulation by sympathetic innervation provides a molecular basis for establishment and maintenance of autonomic axo-axonal synaptic interactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 22:59:17