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Titolo:
Interaction of the C-terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1
Autore:
El Far, O; Airas, J; Wischmeyer, E; Nehring, RB; Karschin, A; Betz, H;
Indirizzi:
Max Planck Inst Brain Res, Dept Neurochem, D-60528 Frankfurt, Germany Max Planck Inst Brain Res Frankfurt Germany D-60528 8 Frankfurt, Germany Max Planck Inst Biophys Chem, D-37070 Gottingen, Germany Max Planck Inst Biophys Chem Gottingen Germany D-37070 ottingen, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 12, volume: 12, anno: 2000,
pagine: 4215 - 4221
SICI:
0953-816X(200012)12:12<4215:IOTCTR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-GAMMA-SUBUNITS; CALMODULIN-BINDING; CHANNELS; PHOSPHORYLATION; MODULATION; RECOGNITION; DOMAINS;
Keywords:
mGluR; PDZ domain; rat; yeast two-hybrid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Betz, H Max Planck Inst Brain Res, Dept Neurochem, Deutschordenstr 46, D-60528 Frankfurt, Germany Max Planck Inst Brain Res Deutschordenstr 46 Frankfurt Germany D-60528
Citazione:
O. El Far et al., "Interaction of the C-terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1", EUR J NEURO, 12(12), 2000, pp. 4215-4221

Abstract

Group III metabotropic glutamate receptors (mGluRs) are highly enriched inthe presynaptic terminals of glutamatergic synapses where they mediate feedback inhibition of neurotransmitter release. Here, we used the yeast two-hybrid system to identify a direct interaction of the C-terminal tail regionof mGluR7 with the rat homologue of the protein kinase C substrate PICK1. This interaction is specifically mediated by the very C-terminal amino acids of the receptor and can be reconstituted in human embryonic kidney 293 cells by transfection of full-length mGluR7 and PICK1 cDNAs. Quantitative beta -galactosidase assays revealed that among the different group III mGluRs,mGluR7 is the major PICK1 binding partner although other subfamily memberscan also interact with PICK1. These data indicate that PDZ domain-containing proteins might contribute to the presynaptic localization of group ill mGluRs.

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Documento generato il 22/09/20 alle ore 10:08:20