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Titolo:
Distribution of glycine receptor subunits on primate retinal ganglion cells: a quantitative analysis
Autore:
Lin, B; Martin, PR; Solomon, SG; Grunert, U;
Indirizzi:
Univ Sydney, Dept Physiol F13, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 ol F13, Sydney, NSW 2006, Australia Univ Sydney, Inst Biomed Res, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 ed Res, Sydney, NSW 2006, Australia
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 12, volume: 12, anno: 2000,
pagine: 4155 - 4170
SICI:
0953-816X(200012)12:12<4155:DOGRSO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MARMOSET CALLITHRIX-JACCHUS; NEW-WORLD MONKEY; CAT RETINA; MAMMALIAN RETINA; ALPHA-1 SUBUNIT; BIPOLAR CELLS; SPINAL-CORD; ELECTRON-MICROSCOPY; GABA(A) RECEPTOR; SYNAPTIC INPUT;
Keywords:
common marmoset Callithrix jacchus; midget ganglion cells; New World monkey; parasol ganglion cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Grunert, U Univ Sydney, Dept Physiol F13, Sydney, NSW 2006, Australia UnivSydney Sydney NSW Australia 2006 ney, NSW 2006, Australia
Citazione:
B. Lin et al., "Distribution of glycine receptor subunits on primate retinal ganglion cells: a quantitative analysis", EUR J NEURO, 12(12), 2000, pp. 4155-4170

Abstract

This study investigates the distribution of inhibitory neurotransmitter receptors on sensory neurons. Ganglion cells in the retina of a New World monkey, the common marmoset Callithrix jacchus, were injected with Lucifer yellow and Neurobiotin and subsequently processed with antibodies against one (alpha1), or against all subunits, of the glycine receptor, or against the anchoring protein gephyrin. Immunoreactive (IR) puncta representing glycinereceptor or gephyrin clusters were found on the proximal and the distal dendrites of all ganglion cell types investigated. For both parasol and midget cells, the density of receptor clusters was greater on distal than proximal dendrites for all antibodies tested. In parasol cells the average density for the alpha1 subunit of the glycine receptor was 0.087 IR puncta/mum ofdendrite, and for all subunits it was 0.119 IR puncta/mum of dendrite. Thus, the majority of glycine receptors on parasol cells contain the alpha1 subunit. For parasol cells, we estimated an average of 1.5 glycinergic synapses/100 mum(2) dendritic membrane on proximal dendrites and about 9.4 glycinergic synapses/100 mum(2) on distal dendrites. The segregation of receptorsto the distal dendrites appears to be a common feature of inhibitory neurotransmitter input to parasol and midget cells, and might be associated withthe receptive field surround mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:24:50