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Titolo:
The high frequency of coeliac disease among children with neurological disorders
Autore:
Salur, L; Uibo, O; Talvik, I; Justus, I; Metskula, K; Talvik, T; Uibo, R;
Indirizzi:
Univ Tartu, Dept Immunol, EE-51014 Tartu, Estonia Univ Tartu Tartu Estonia EE-51014 Dept Immunol, EE-51014 Tartu, Estonia Univ Tartu, Dept Paediat, EE-51014 Tartu, Estonia Univ Tartu Tartu Estonia EE-51014 Dept Paediat, EE-51014 Tartu, Estonia
Titolo Testata:
EUROPEAN JOURNAL OF NEUROLOGY
fascicolo: 6, volume: 7, anno: 2000,
pagine: 707 - 711
SICI:
1351-5101(200011)7:6<707:THFOCD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELIAC-DISEASE; DOWN-SYNDROME; TISSUE TRANSGLUTAMINASE; ANTIENDOMYSIUM ANTIBODIES; EPILEPSY; CALCIFICATIONS; ANTIGLIADIN; AUTOANTIGEN; DEFICIENCY; PREVALENCE;
Keywords:
antiendomysium antibodies; antigliadin antibodies; antireticulin antibodies; coeliac disease; neurological disorders; screening;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Uibo, R Univ Tartu, Dept Immunol, 19 Ravila St, EE-51014 Tartu, Estonia Univ Tartu 19 Ravila St Tartu Estonia EE-51014 014 Tartu, Estonia
Citazione:
L. Salur et al., "The high frequency of coeliac disease among children with neurological disorders", EUR J NEUR, 7(6), 2000, pp. 707-711

Abstract

In the present study we have explored antigliadin (AGA) and antireticulin (ARA) antibody tests for the serological screening for coeliac disease (CD)of 206 children with neurological disorders. IgA- or/and IgG-type AGA was discovered in 17 (8.3%) patients and IgA-type ARA in one (0.5%) patient. A small intestinal biopsy was performed in all 18 antibody-positive patients,and villous atrophy compatible with CD was revealed in three cases (patients with either epilepsy retardation of psychomotor development or Down's syndrome). The CD prevalence rate of 14.6 per 1000 (95% CI 7.0-22.2) found inthe present study was higher than could have been anticipated on the basisof the results of our previous population studies, which indicate that CD occurs more frequently among children with neurological disorders (OR = 37.6; 95% CI 9.7-146.9). Whether this finding reflects certain immunopathogenic links between CD and particular neurological diseases needs to be studiedfurther. In this study, we were unable, using indirect immunofluorescence testing, to demonstrate the presence of autoantibodies against brain tissuein CD and AGA-positive patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:54:20