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Titolo:
EFNS Task Force Report: a questionnaire-based survey on the service provision and quality assurance for determination of diagnostic autoantibody tests in European neuroimmunology centres
Autore:
Willison, HJ; Ang, W; Gilhus, NE; Graus, F; Liblau, R; Vedeler, C; Vincent, A;
Indirizzi:
Univ Glasgow, So Gen Hosp, Dept Neurol, Inst Neurol Sci, Glasgow G51 4TF, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G51 4TF ow G51 4TF, Lanark, Scotland Univ Hosp Dijkzigt, NL-3015 GD Rotterdam, Netherlands Univ Hosp Dijkzigt Rotterdam Netherlands NL-3015 GD tterdam, Netherlands Haukeland Univ Hosp, Dept Neurol, N-5021 Bergen, Norway Haukeland Univ Hosp Bergen Norway N-5021 t Neurol, N-5021 Bergen, Norway Hosp Clin Barcelona, Serv Neurol, E-08036 Barcelona, Spain Hosp Clin Barcelona Barcelona Spain E-08036 ol, E-08036 Barcelona, Spain Hop La Pitie Salpetriere, F-75651 Paris 13, France Hop La Pitie Salpetriere Paris France 13 riere, F-75651 Paris 13, France John Radcliffe Hosp, Inst Mol Med, Dept Clin Neurol, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU urol, Oxford OX3 9DU, England
Titolo Testata:
EUROPEAN JOURNAL OF NEUROLOGY
fascicolo: 6, volume: 7, anno: 2000,
pagine: 625 - 628
SICI:
1351-5101(200011)7:6<625:ETFRAQ>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARANEOPLASTIC CEREBELLAR DEGENERATION; EATON-MYASTHENIC-SYNDROME; STIFF-MAN SYNDROME; NEUROLOGICAL DISORDERS; BREAST-CANCER; ANTIBODY; AUTOIMMUNITY; CHANNELS; PROTEIN; ASSAYS;
Keywords:
autoantibody; neuroimmunology centres; quality assurance; service provision;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Willison, HJ Univ Glasgow, So Gen Hosp, Dept Neurol, Inst Neurol Sci, Glasgow G51 4TF, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G51 4TFanark, Scotland
Citazione:
H.J. Willison et al., "EFNS Task Force Report: a questionnaire-based survey on the service provision and quality assurance for determination of diagnostic autoantibody tests in European neuroimmunology centres", EUR J NEUR, 7(6), 2000, pp. 625-628

Abstract

Autoantibodies to a wide variety of neural components are frequently sought in the sera of patients with neurological diseases suspected to have an antibody-associated autoimmune basis. Variations in assay methodology and availability are likely to exist throughout European diagnostic immunology centres, and interlaboratory discrepancies in performance for some assays have been reported. The availability of quality assurance is largely unknown. In this questionnaire-based EFNS task force, all 18 national representatives of the Neuroimmunology Panel within the EFNS were invited to estimate theservice provision within their country; 12 panel members responded. From these responses, it emerged that a range of assays are being performed throughout European centres, involving over 20 separate antigens, using a broad array of immunodetection techniques. With the exception of the estimation of anti-AChR antibodies for the diagnosis of myasthenia gravis, no systematic quality assurance schemes are available, this being conducted on an ad hoc basis, or not at all. Since quality is a central component of assay sensitivity and specificity, we conclude that there is an urgent need to introduce pan-European quality assurance schemes, based on provision of positive and negative test sera from a central source, and in which all neuroimmunology laboratories should participate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:29:01