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Titolo:
Relationship between left ventricular wall stress and ANP gene expression during the evolution of rapid ventricular pacing-induced heart failure in the dog
Autore:
Luchner, A; Borgeson, DD; Grantham, JA; Friedrich, E; Riegger, GAJ; Burnett, JC; Redfield, MM;
Indirizzi:
Univ Regensburg, Klin & Poliklin Innere Med 2, D-93042 Regensburg, GermanyUniv Regensburg Regensburg Germany D-93042 , D-93042 Regensburg, Germany Mayo Clin, Div Cardiovasc Dis, Cardiorenal Res Lab, Rochester, MN USA MayoClin Rochester MN USA c Dis, Cardiorenal Res Lab, Rochester, MN USA
Titolo Testata:
EUROPEAN JOURNAL OF HEART FAILURE
fascicolo: 4, volume: 2, anno: 2000,
pagine: 379 - 386
SICI:
1388-9842(200012)2:4<379:RBLVWS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-FACTOR; SPONTANEOUSLY HYPERTENSIVE RATS; ANGIOTENSIN-II; RECEPTOR ANTAGONIST; ENDOTHELIN ET(A); CANINE MODEL; HYPERTROPHY; PEPTIDE; POLYPEPTIDE; TACHYCARDIA;
Keywords:
LV hypertrophy; pacing; dog; gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Luchner, A Univ Regensburg, Klin & Poliklin Innere Med 2, FJ Strauss Allee11, D-93042 Regensburg, Germany Univ Regensburg FJ Strauss Allee 11 Regensburg Germany D-93042
Citazione:
A. Luchner et al., "Relationship between left ventricular wall stress and ANP gene expression during the evolution of rapid ventricular pacing-induced heart failure in the dog", EUR J HE FA, 2(4), 2000, pp. 379-386

Abstract

We have recently described a modified model of progressive rapid ventricular pacing-induced heart failure which evolves over a period of 38 days. To further characterize left ventricular remodeling during the progression of heart failure, we assessed left ventricular geometry, wall stress, and atrial natriuretic peptide (ANP) gene expression and protein content during control conditions, asymptomatic left ventricular dysfunction, and overt congestive heart failure (CHF). Although asymptomatic left ventricular dysfunction was characterized by a significant increase in systolic and diastolic left ventricular dimension (+30% and +6%, respectively, P < 0.05 each) and a marked increase in left ventricular systolic wall stress (+68%, P < 0.01), left ventricular ANP gene expression was unchanged as compared to control. In contrast, strong left Ventricular ANP gene expression (+449%, P < 0.05) was observed during overt CHF in the absence of further significant increases in left ventricular systolic wall stress. The onset of strong left ventricular ANP gene expression was associated with increased ANP content (+88%,P < 0.05) and left ventricular mass index (+13%, P < 0.05). In contrast, left atrial ANP gene expression and left ventricular diastolic wall stress increased progressively during asymptomatic left ventricular dysfunction (+39%, P = n.s. and +131%, P < 0.01) and overt CHF (+76% and +336% vs. control, P < 0.01 each). Progressive rapid Ventricular pacing is associated with the induction of left ventricular ANP gene expression and protein synthesis exclusively during overt CHF. The current studies provide new insight into the temporal pattern of ANP-activation and the disparity between left ventricular systolic wall stress and ANP-activation in a large animal model of progressive CHF. (C) European Society of Cardiology. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 14:52:46