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Titolo:
Zaleplon and triazolam physical dependence assessed across increasing doses under a once-daily dosing regimen in baboons
Autore:
Ator, NA; Weerts, EM; Kaminski, BJ; Kautz, MA; Griffiths, RR;
Indirizzi:
Johns Hopkins Univ, Sch Med, Behav Biol Res Ctr, Dept Psychiat & Behav Sci, Baltimore, MD 21224 USA Johns Hopkins Univ Baltimore MD USA 21224 av Sci, Baltimore, MD 21224 USA
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 1, volume: 61, anno: 2000,
pagine: 69 - 84
SICI:
0376-8716(200012)61:1<69:ZATPDA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TERM CONTINUOUS AVAILABILITY; SELF-INJECTION; BENZODIAZEPINE ANTAGONIST; BEHAVIORAL PHARMACOLOGY; PRECIPITATED WITHDRAWAL; RHESUS-MONKEYS; RO 15-1788; DIAZEPAM; TOLERANCE; PHARMACOKINETICS;
Keywords:
abuse potential; benzodiazepine; CL 284 846; dependence; feeding; triazolam; zaleplon;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Ator, NA Johns Hopkins Univ, Sch Med, Behav Biol Res Ctr, Dept Psychiat & Behav Sci, Ste 3000,5510 Nathan Shock Dr,John Hopkins Bayview, Baltimore, MD 21224 USA Johns Hopkins Univ Ste 3000,5510 Nathan Shock Dr,John Hopkins Bayview Baltimore MD USA 21224
Citazione:
N.A. Ator et al., "Zaleplon and triazolam physical dependence assessed across increasing doses under a once-daily dosing regimen in baboons", DRUG AL DEP, 61(1), 2000, pp. 69-84

Abstract

The ability of the GABA(A)-receptor-subtype-selective hypnotic zaleplon toproduce physical dependence was compared to the nonselective benzodiazepine triazolam. Progressively increasing doses of zaleplon and triazolam were given to baboons by intragastric infusion once each day, with doses increasing every 17 days. Next, the highest dose was given for 10-34 additional days by continuous infusion. Both drugs produced increases in food-maintainedlever pressing, ataxia, and time to complete a fine motor task. Plasma levels increased dose-dependently; drug was detectable 24 h after higher doses. Flumazenil produced a mild or intermediate precipitated-withdrawal syndrome on day 14 of all dosing conditions. When drug delivery ended after 85-100 days, a benzodiazepine-type withdrawal syndrome occurred. Physical dependence potential of zaleplon and triazolam appear similar. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:47:08