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Titolo:
Zaleplon and triazolam: drug discrimination, plasma levels, and self-administration in baboons
Autore:
Ator, NA;
Indirizzi:
Johns Hopkins Univ, Sch Med, Behav Biol Res Ctr, Dept Psychiat & Behav Sci, Baltimore, MD 21224 USA Johns Hopkins Univ Baltimore MD USA 21224 av Sci, Baltimore, MD 21224 USA
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 1, volume: 61, anno: 2000,
pagine: 55 - 68
SICI:
0376-8716(200012)61:1<55:ZATDDP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE RECEPTORS; BEHAVIORAL PHARMACOLOGY; PHYSICAL-DEPENDENCE; TRAINING CONDITIONS; STIMULUS PROPERTIES; ZOLPIDEM; PHARMACOKINETICS; RATS; CL-284,846; LORAZEPAM;
Keywords:
abuse potential; CL 284,846; drug discrimination; feeding; flumazenil; pharmacokinetics; self-administration; triazolam; zaleplon; zolpidem;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Ator, NA Johns Hopkins Univ, Sch Med, Behav Biol Res Ctr, Dept Psychiat & Behav Sci, John Hopkins Bayview Campus,5510 Nathan Shock Dr,, Baltimore, MD21224 USA Johns Hopkins Univ John Hopkins Bayview Campus,5510 Nathan ShockDr, Baltimore MD USA 21224
Citazione:
N.A. Ator, "Zaleplon and triazolam: drug discrimination, plasma levels, and self-administration in baboons", DRUG AL DEP, 61(1), 2000, pp. 55-68

Abstract

Zaleplon is a chemically novel hypnotic that preferentially binds alpha (1)-subunit containing subtypes of the alpha beta gamma configuration of the gamma -aminobutyric acid (GABA)(A) receptor. Zaleplon and the non-subtype-selective hypnotic triazolam occasioned 100% drug-appropriate responding in baboons trained to discriminate lorazepam or pentobarbital from vehicle. Flumazenil shifted the zaleplon generalization gradient at least five-fold tothe right. A plasma elimination half-life of 6-8 h for oral 10 mg/kg zaleplon and 0.32 mg/kg triazolam was paralleled by discriminative control for 7h. Zaleplon maintained self-injection greater than vehicle, as did comparison doses of the similarly selective hypnotic zolpidem and triazolam. Concurrent food-maintained responding increased during self-injection of all three drugs. Preferential binding at this alpha (1)-containing GABA, subtype did not diminish the benzodiazepine (Bzs)-like behavioral effects of zaleplon. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:00:29