Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pyridoxine-induced photosensitivity and hypophosphatasia
Autore:
Kawada, A; Kashima, A; Shiraishi, H; Gomi, H; Matsuo, I; Yasuda, K; Sasaki, G; Sato, S; Orimo, H;
Indirizzi:
Kinki Univ, Sch Med, Dept Dermatol, Osaka 5898511, Japan Kinki Univ Osaka Japan 5898511 Med, Dept Dermatol, Osaka 5898511, Japan Teikyo Univ, Sch Med, Ichihara Hosp, Dept Dermatol, Chiba, Japan Teikyo Univ Chiba Japan Med, Ichihara Hosp, Dept Dermatol, Chiba, Japan Kagawa Nutr Univ, Dept Clin Chem, Sakado, Saitama, Japan Kagawa Nutr UnivSakado Saitama Japan Clin Chem, Sakado, Saitama, Japan Keio Univ, Sch Med, Dept Pediat, Tokyo, Japan Keio Univ Tokyo JapanKeio Univ, Sch Med, Dept Pediat, Tokyo, Japan Nippon Med Sch, Dept Biochem & Mol Biol, Tokyo 113, Japan Nippon Med Sch Tokyo Japan 113 Dept Biochem & Mol Biol, Tokyo 113, Japan
Titolo Testata:
DERMATOLOGY
fascicolo: 4, volume: 201, anno: 2000,
pagine: 356 - 360
SICI:
1018-8665(2000)201:4<356:PPAH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALKALINE-PHOSPHATASE; PYRIDOXAL-5'-PHOSPHATE LEVELS; VITAMIN-B6 METABOLISM; HYDROCHLORIDE;
Keywords:
photosensitivity; vitamin B-6; pyridoxine hydrochloride; pyridoxal 5 '-phosphate; metabolism; hypophosphatasia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kawada, A Kinki Univ, Sch Med, Dept Dermatol, 377-2 Ohno Higashi, Osaka 5898511, Japan Kinki Univ 377-2 Ohno Higashi Osaka Japan 5898511 898511, Japan
Citazione:
A. Kawada et al., "Pyridoxine-induced photosensitivity and hypophosphatasia", DERMATOLOGY, 201(4), 2000, pp. 356-360

Abstract

We describe a case of photosensitivity due to pyridoxine hydrochloride (vitamin B-6) in a heterozygote of hypophosphatasia. Photopatch tests using pyridoxine hydrochloride and pyridoxal 5'-phosphate, compounds referred to asvitamin B-6, with ultraviolet light A irradiation were positive. Laboratory examination showed low serum alkaline phosphatase. Tissue-nonspecific alkaline phosphatase exon amplification from DNA of the patient's lymphocytes detected deletion 1154-1156 hypophosphatasia mutation, indicating that thispatient was diagnosed to be a heterozygote of hypophosphatasia. The seric pyridoxal 5'-phosphate level of this patient with hypophosphatasia was higher than in normals. Furthermore, after oral administration of vitamin B-6 this level increased greatly and long-lastingly, and this might be related to the low level of alkaline phosphatase in this patient. Photosensitivity in this patient may have been caused by abnormal metabolism of vitamin B-6 under the hypophosphatic condition. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:18:17