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Titolo:
Aneuploidy in human sperm: a review of the frequency and distribution of aneuploidy, effects of donor age and lifestyle factors
Autore:
Shi, Q; Martin, RH;
Indirizzi:
Alberta Childrens Prov Gen Hosp, Dept Genet, Calgary, AB T2T 5C7, Canada Alberta Childrens Prov Gen Hosp Calgary AB Canada T2T 5C7 T2T 5C7, Canada Univ Calgary, Fac Med, Dept Med Genet, Calgary, AB, Canada Univ Calgary Calgary AB Canada Med, Dept Med Genet, Calgary, AB, Canada
Titolo Testata:
CYTOGENETICS AND CELL GENETICS
fascicolo: 3-4, volume: 90, anno: 2000,
pagine: 219 - 226
SICI:
0301-0171(2000)90:3-4<219:AIHSAR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU-HYBRIDIZATION; SEX-CHROMOSOME ANEUPLOIDY; PATERNAL AGE; HUMAN-SPERMATOZOA; MULTICOLOR FISH; 3-COLOR FISH; TRANSLOCATION CARRIER; Y-CHROMOSOME; STRUCTURAL ABNORMALITIES; ACROCENTRIC CHROMOSOMES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Martin, RH Alberta Childrens Prov Gen Hosp, Dept Genet, 1820 Richmond Rd SW, Calgary,AB T2T 5C7, Canada Alberta Childrens Prov Gen Hosp 1820 RichmondRd SW Calgary AB Canada T2T 5C7
Citazione:
Q. Shi e R.H. Martin, "Aneuploidy in human sperm: a review of the frequency and distribution of aneuploidy, effects of donor age and lifestyle factors", CYTOG C GEN, 90(3-4), 2000, pp. 219-226

Abstract

Application of fluorescence in situ hybridization (FISH) analysis has opened the way for comprehensive studies on numerical chromosome abnormalities in human sperm. During the last decade, more than five million sperm from approximately 500 normal men were analyzed by a number of laboratories from around the world by this approach. Except for chromosome 19 which has been analyzed in only one study, all other chromosomes have been examined by twoor more studies with considerable differences in disomy frequency for an individual chromosome among studies. The mean disomy frequency is 0.15 % foreach of the autosomes and 0.26 % for the sex chromosomes. Most chromosomesanalyzed have an equal distribution of disomy with the exception of chromosomes 14, 21, 22 and the sex chromosomes, which display significantly higher disomy frequencies. Slight but significant increases in disomy frequency with advancing paternal age were observed for some chromosomes, in particular for the sex chromosomes. Some lifestyle factors such as smoking, alcoholdrinking and caffeine consumption have been investigated and no consistentassociation between disomy frequency and any type of lifestyle factors hasbeen established. The question of whether different geographic and ethnic groups of men have inherent differences in frequency of disomic sperm has been investigated by two studies with conflicting results. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 05:35:27