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Titolo:
Suppression by verapamil of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats
Autore:
Iishi, H; Tatsuta, M; Baba, M; Yano, H; Sakai, N; Uehara, H; Nakaizumi, A;
Indirizzi:
Osaka Med Ctr Canc & Cardiovasc Dis, Dept Gastrointestinal Oncol, Higashinari Ku, Osaka 5378511, Japan Osaka Med Ctr Canc & Cardiovasc Dis Osaka Japan 5378511 a 5378511, Japan
Titolo Testata:
CHEMOTHERAPY
fascicolo: 1, volume: 47, anno: 2001,
pagine: 70 - 76
SICI:
0009-3157(200101/02)47:1<70:SBVOBP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING PROTEIN; MONOCLONAL-ANTIBODY; GINSENOSIDE RG(3); CARCINOMA-CELLS; INVASION; CANCER; INHIBITION; GROWTH; CARCINOGENESIS; CALMODULIN;
Keywords:
bombesin; metastasis; verapamil; intestinal adenocarcinoma; azoxymethane; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Iishi, H Osaka Med Ctr Canc & Cardiovasc Dis, Dept Gastrointestinal Oncol,Higashinari Ku, 3-3 Nakamichi 1 Chome, Osaka 5378511, Japan Osaka Med Ctr Canc & Cardiovasc Dis 3-3 Nakamichi 1 Chome Osaka Japan 5378511
Citazione:
H. Iishi et al., "Suppression by verapamil of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats", CHEMOTHERA, 47(1), 2001, pp. 70-76

Abstract

Background: The effects of combined administration of bombesin and verapamil hydrochloride (verapamil), a calcium channel blocker, on the incidence of peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane (AOM) and the labeling index of intestinal cancers were investigated in male Wistar rats. Methods: From the beginning of the experiment, rats were given 10 weekly subcutaneous injections of AOM (7.4 mg/kg body weight) and subcutaneous injections of bombesin (40 mug/kg body weight) every other day, and from week 16, intraperitoneal injections of verapamil (10 or 20 mg/kgbody weight) every other day until the end fo the experiment in week 45. Results: Bombesin significantly increased the incidence of intestinal tumorsand cancer metastasis to the peritoneum. Although verapamil administered at either dose had little or no effect on the enhancement of intestinal carcinogenesis by bombesin or on the location, histologic type, depth of involvement, labeling index, apoptotic index or tumor vascularity of intestinal cancers, it significantly decreased the incidence of cancer metastasis. Verapamil also significantly decreased the incidence of lymphatic invasion of adenocarcinomas, which was enhanced by bombesin. Conclusion: These findings indicate that verapamil inhibits cancer metastasis through actions that do not affect the growth of intestinal cancers. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 21:45:59