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Titolo:
Fibroblast growth factors are required for efficient tumor angiogenesis
Autore:
Compagni, A; Wilgenbus, P; Impagnatiello, MA; Cotten, M; Christofori, G;
Indirizzi:
Res Inst Mol Pathol, A-1030 Vienna, Austria Res Inst Mol Pathol Vienna Austria A-1030 Pathol, A-1030 Vienna, Austria
Titolo Testata:
CANCER RESEARCH
fascicolo: 24, volume: 60, anno: 2000,
pagine: 7163 - 7169
SICI:
0008-5472(200012)60:24<7163:FGFARF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CELL TUMORS; ENDOTHELIAL-CELLS; FACTOR RECEPTOR; MULTISTAGE TUMORIGENESIS; PANCREATIC-ISLETS; IN-VIVO; EXPRESSION; SUPPRESSION; PROGRESSION; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Christofori, G Res Inst Mol Pathol, Dr Bohr Gasse 7, A-1030 Vienna, Austria Res Inst Mol Pathol Dr Bohr Gasse 7 Vienna Austria A-1030
Citazione:
A. Compagni et al., "Fibroblast growth factors are required for efficient tumor angiogenesis", CANCER RES, 60(24), 2000, pp. 7163-7169

Abstract

Although the function of vascular endothelial growth factor in the induction of tumor angiogenesis is well understood, the role of a second group of angiogenic factors, the fibroblast growth factors (FGFs), remains elusive. We used a recombinant adenovirus expressing soluble FGF receptor (AdsFGFR) to interfere with FGF function in tumor angiogenesis, AdsFGFR repressed endothelial cell proliferation in vitro and inhibited tumor angiogenesis in anex vivo bioassay, in which endothelial cells were cocultured with angiogenic tumor biopsies in a collagen gel. Moreover, AdsFGFR repressed tumor angiogenesis and hence tumor growth in vivo in allograft transplantation experiments. Whereas adenoviral expression of a soluble form of VEGF receptor 1 (AdsFlt) predominantly affected the initiation of tumor angiogenesis, soluble FGF receptor (sFGFR) appeared to impair the maintenance of tumor angiogenesis. The combination of sFGFR and soluble Fit exhibited a synergistic effect in the repression of tumor growth, Finally, i.v. injection of AdsFGFR resulted in a dramatic repression of tumor growth in a transgenic mouse modelof pancreatic beta cell carcinogenesis. Similar to control infections withAdsFlt, tumor-associated vessel density was decreased, indicating that theexpression of sFGFR impaired tumor angiogenesis. These data indicate that FGFs play a critical role in tumor angiogenesis.

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Documento generato il 03/12/20 alle ore 15:37:04