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Titolo:
Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entrycapacity
Autore:
Krasnykh, V; Dmitriev, I; Navarro, JG; Belousova, N; Kashentseva, E; Xiang, JL; Douglas, JT; Curiel, DT;
Indirizzi:
Univ Alabama, Div Human Gene Therapy, Lerleen Wallace Tumor Inst 620, DeptMed, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 0, DeptMed, Birmingham, AL 35294 USA Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 ept Pathol, Birmingham, AL 35294 USA Univ Alabama, Dept Surg, Birmingham, AL 35294 USA Univ Alabama BirminghamAL USA 35294 Dept Surg, Birmingham, AL 35294 USA Univ Alabama, Gene Therapy Ctr, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 herapy Ctr, Birmingham, AL 35294 USA
Titolo Testata:
CANCER RESEARCH
fascicolo: 24, volume: 60, anno: 2000,
pagine: 6784 - 6787
SICI:
0008-5472(200012)60:24<6784:AGAVPA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIRWAY EPITHELIA; CATIONIC LIPIDS; FIBER PROTEIN; TRANSGENE EXPRESSION; OVARIAN-CANCER; HI LOOP; IN-VIVO; DELIVERY; CELLS; INFECTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Curiel, DT Univ Alabama, Div Human Gene Therapy, Lerleen Wallace Tumor Inst 620, DeptMed, 1824 6th Ave S, Birmingham, AL 35294 USA Univ Alabama 1824 6th Ave S Birmingham AL USA 35294 L 35294 USA
Citazione:
V. Krasnykh et al., "Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entrycapacity", CANCER RES, 60(24), 2000, pp. 6784-6787

Abstract

Adenoviral (Ad) vectors have been widely used in the context of cancer gene therapy approaches. Their utility in these contexts, however, has frequently been limited by tumor cell resistance to Ad infection. The basis of this resistance has been defined recently as resulting from a deficiency of the primary adenovirus receptor, coxsackie adenovirus receptor. As a means tocircumvent this Limitation, a variety of tropism modification strategies have allowed coxsackie adenovirus receptor-independent gene delivery via theAd vector, These advanced generation adenovirus vectors exhibit enhanced infectivity, which can allow direct therapeutic gain. Such vectors may allowimprovements in efficacy in the context of ongoing human clinical gene therapy approaches for cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:17:08