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Titolo:
Granulomatous osteonecrosis in Crohn's disease
Autore:
Freeman, HJ; Owen, D; Millan, M;
Indirizzi:
Univ British Columbia, Dept Med Gastroenterol, Vancouver, BC V5Z 1M9, Canada Univ British Columbia Vancouver BC Canada V5Z 1M9 ver, BC V5Z 1M9, Canada
Titolo Testata:
CANADIAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 11, volume: 14, anno: 2000,
pagine: 951 - 954
SICI:
0835-7900(200012)14:11<951:GOICD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; ARTHRITIS; NECROSIS; PATIENT;
Keywords:
avascular necrosis; corticosteroids; Crohn's disease; granulomatous bone disease; osteonecrosis; ulcerative colitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Freeman, HJ Univ British Columbia Hosp, ACU F-137,2211 Wesbrook Mall, Vancouver, BC V6T 1W5, Canada Univ British Columbia Hosp ACU F-137,2211 Wesbrook Mall Vancouver BC Canada V6T 1W5
Citazione:
H.J. Freeman et al., "Granulomatous osteonecrosis in Crohn's disease", CAN J GASTR, 14(11), 2000, pp. 951-954

Abstract

A 25-year-old white woman was diagnosed with Crohn's disease involving thesmall and large intestines. She had a complex clinical course that required treatment with multiple pharmacological agents, including intravenous, oral and rectal corticosteroids. She also received parenteral nutrition with lipid emulsions. Finally, repeated intestinal resections and drainage of perianal abscesses were required. Her disease was complicated by gallstones, urolithiasis and hip pain. After osteonecrosis was diagnosed, joint replacements were performed. Review of the pathological sections from the resectedhip, however, resulted in detection of granulomatous inflammation with multinucleated giant cells - the histological 'footprint' of Crohn's disease in the gastrointestinal tract. Because prior specialized perfusion fixation pathological studies of the intestine in Crohn's disease have shown that granulomas are located in the walls of blood vessels, a possible mechanism for the pathogenesis of osteonecrosis in Crohn's disease is chronic microvascular ischemia of bone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:16:22