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Titolo:
Afferents to the central nucleus of the amygdala and functional subdivisions of the periaqueductal gray: neuroanatomical substrates for affective behavior
Autore:
Paredes, J; Winters, RW; Schneiderman, N; McCabe, PM;
Indirizzi:
Univ Miami, Dept Psychol, Coral Gables, FL 33124 USA Univ Miami Coral Gables FL USA 33124 Psychol, Coral Gables, FL 33124 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 887, anno: 2000,
pagine: 157 - 173
SICI:
0006-8993(200012)887:1<157:ATTCNO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETROGRADE AXONAL-TRANSPORT; ORTHOGRADE HORSERADISH-PEROXIDASE; MEDIAL PREFRONTAL CORTEX; DEFENSE REACTION; ELECTRICAL-STIMULATION; CORTICAL PROJECTIONS; BRAIN-STEM; CARDIOVASCULAR-RESPONSES; TRACING TECHNIQUES; KAINIC ACID;
Keywords:
central nucleus of the amygdala; periaqueductal gray; hypothalamus; medial prefrontal cortex; neuroanatomical tracer; emotional stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: McCabe, PM Univ Miami, Dept Psychol, POB 248185, Coral Gables, FL 33124 USA Univ Miami POB 248185 Coral Gables FL USA 33124 s, FL 33124 USA
Citazione:
J. Paredes et al., "Afferents to the central nucleus of the amygdala and functional subdivisions of the periaqueductal gray: neuroanatomical substrates for affective behavior", BRAIN RES, 887(1), 2000, pp. 157-173

Abstract

Evidence suggests the periaqueductal gray (PAG) is involved in the integration of behavioral and autonomic components of affective behavior. Our laboratory has shown that electrical stimulation of the ventrolateral periaqueductal gray (vl FAG) versus the dorsolateral periaqueductal gray (dl FAG), in the rabbit, elicits two distinct behavioral/cardiorespiratory response patterns. Furthermore, evidence suggests that the amygdaloid central nucleus (ACe) may influence cardiovascular activity during emotional states. The purpose of this study was to delineate the topography and determine the origin of forebrain projections to the FAG and the ACe, as well as commonalties and differences in the pattern of afferents. Examination of common afferents may lend insights into their function as components of a forebrain systemregulating autonomic activity during emotional states. Separate retrogradetracers were injected into functional subdivisions of the FAG and the ACe in rabbits. FAG injections led to neuronal labeling in numerous cortical regions including the ipsilateral medial prefrontal and insular cortices. Additionally, bilateral labeling was observed in several hypothalamic nuclei including the paraventricular nucleus, the dorsomedial nucleus and the ventromedial nucleus as well as the region lateral to the descending column of the fornix. Sparse labeling was also seen in various basal forebrain regions, thalamic nuclei and amygdaloid nuclei. Many of these regions were also labeled following injections in the ACe. Although double-labeled cells were never observed, afferents to the ACe were often proximal to FAG afferents. Implications of these findings are discussed in terms of two functionally distinct behavioral/cardiovascular response patterns. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 05/04/20 alle ore 06:30:57