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Titolo:
Tonic inhibition of food intake during inactive phase is reversed by the injection of the melanocortin receptor antagonist into the paraventricular nucleus of the hypothalamus and central amygdala of the rat
Autore:
Kask, A; Schioth, HB;
Indirizzi:
Univ Tartu, Fac Med, Dept Pharmacol, EE-51014 Tartu, Estonia Univ Tartu Tartu Estonia EE-51014 ept Pharmacol, EE-51014 Tartu, Estonia Uppsala Univ, Dept Neurosci, Uppsala, Sweden Uppsala Univ Uppsala Sweden ppsala Univ, Dept Neurosci, Uppsala, Sweden
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 887, anno: 2000,
pagine: 460 - 464
SICI:
0006-8993(200012)887:2<460:TIOFID>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOCYTE-STIMULATING HORMONE; FEEDING-BEHAVIOR; GENE-EXPRESSION; NEUROPEPTIDE-Y; BODY-WEIGHT; C-FOS; BRAIN; OBESITY; GALANIN; HS014;
Keywords:
feeding; melanocortin receptor; MC4 receptor antagonist, HS014; amygdala; nucleus accumbens; paraventricular nucleus; hypothalamus; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Kask, A Douglas Hosp, Res Ctr, 6875 Boul LaSalle, Verdun, PQ H4H 1R3, Canada Douglas Hosp 6875 Boul LaSalle Verdun PQ Canada H4H 1R3 R3, Canada
Citazione:
A. Kask e H.B. Schioth, "Tonic inhibition of food intake during inactive phase is reversed by the injection of the melanocortin receptor antagonist into the paraventricular nucleus of the hypothalamus and central amygdala of the rat", BRAIN RES, 887(2), 2000, pp. 460-464

Abstract

Melanocortins inhibit food intake and melanocortin 4 receptor (MC4R) antagonists stimulate feeding behaviour. These effects may occur due to stimulation or blockade of MC4 receptors in the hypothalamus. To test the validity of this hypothesis, a cyclic peptide, the MC4R selective antagonist HS014 (20, 100 and 500 pmol), or vehicle, was injected unilaterally into the paraventricular nucleus of the hypothalamus (PVN). As MC receptors are expressedalso in extrahypothalamic sites involved in the regulation of feeding behaviour, HS014 was injected bilaterally into the vicinity of the central nucleus of the amygdala (CA) and the nucleus accumbens region (Acc). All doses of HS014 induced a dose-dependent increase in food intake when injected into the PVN. Intra-amygdalar injections of HS014 (50 and 250 pmol/side) also stimulated food intake, whereas a 10-pmol dose was inactive. Local microinjections of HS014 into the Acc failed to stimulate feeding. These data suggest that endogenous melanocortin receptor agonists exert a tonic inhibitory influence on food consumption by stimulating MC4 receptors in the hypothalamus and amygdala. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:00:42