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Titolo:
Dopamine and 5-HT turnover are increased by the mGlu2/3 receptor agonist LY379268 in rat medial prefrontal cortex, nucleus accumbens and striatum
Autore:
Cartmell, J; Salhoff, CR; Perry, KW; Monn, JA; Schoepp, DD;
Indirizzi:
Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA Eli Lilly & CoIndianapolis IN USA 46285 Labs, Indianapolis, IN 46285 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 887, anno: 2000,
pagine: 378 - 384
SICI:
0006-8993(200012)887:2<378:DA5TAI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; SUBSTANTIA NIGRA; FRONTAL-CORTEX; IN-VIVO; BRAIN; METABOLISM; SEROTONIN; RELEASE; DRUGS; RISPERIDONE;
Keywords:
metabotropic glutamate receptor; dopamine; 5-HT; prefrontal cortex; nucleus accumbens; striatum; turnover;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Schoepp, DD Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA EliLilly & Co Indianapolis IN USA 46285 apolis, IN 46285 USA
Citazione:
J. Cartmell et al., "Dopamine and 5-HT turnover are increased by the mGlu2/3 receptor agonist LY379268 in rat medial prefrontal cortex, nucleus accumbens and striatum", BRAIN RES, 887(2), 2000, pp. 378-384

Abstract

We have shown, using in vivo microdialysis sampling, that systemic administration of the selective group II metabotropic (mGlu) receptor agonist LY379268, like the atypical antipsychotic clozapine, increased extracellular levels of dopamine, dopamine metabolites DDPAC and HVA, and the major 5-HT metabolite 5-HIAA, in rat medial prefrontal cortex (mPFC). Here, we have compared the effects of LY379268 with clozapine as well as risperidone on ex vivo tissue levels of dopamine, DOPAC, HVA, 5-HT and 5-HIAA in multiple brainregions. One to two hours following administration of LY379268, mPFC tissue levels of DOPAC, HVA and 5-HIAA were increased in a dose-dependent manner. Increases evoked by LY379268 (10 mg/kg s.c.) at the 2 h point were 189, 245 and 139% of basal-levels, respectively. These effects were reversed within 4 h of administration. Clozapine (10 mg/kg s.c.) and risperidone (1 mg/kg s.c.) also increased levels of the dopamine metabolites to a similar extent but were without significant effect on tissue levels of 5-HIAA. LY379268(10 mg/kg s.c.) also increased tissue levels of DOPAC, HVA and 5-HIAA by 169, 221 and 134% of basal levels in nucleus accumbens, respectively, and by131, 179 and 132% of basal levels in striatum, respectively. These data show that activation of mGlu2/3 receptors can increase the turnover of dopamine and 5-HT in the areas of the brain implicated in the actions of atypicalantipsychotics. (C) 2000 Elsevier Science BSI. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 06:59:13