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Titolo:
Pulse pressure: A predictor of cardiovascular mortality among young normotensive subjects
Autore:
Fang, J; Madhavan, S; Alderman, MH;
Indirizzi:
Yeshiva Univ Albert Einstein Coll Med, Dept Epidemiol & Social Med, Bronx,NY 10461 USA Yeshiva Univ Albert Einstein Coll Med Bronx NY USA 10461 onx,NY 10461 USA
Titolo Testata:
BLOOD PRESSURE
fascicolo: 5, volume: 9, anno: 2000,
pagine: 260 - 266
SICI:
0803-7051(2000)9:5<260:PPAPOC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGE-RELATED-CHANGES; BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; ESSENTIAL-HYPERTENSION; ATHEROSCLEROSIS; ELASTICITY; FRAMINGHAM; DISEASE; RISK;
Keywords:
cardiovascular mortality; epidemiological follow-up; NHANES I; normotensive; pulse pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Fang, J Yeshiva Univ Albert Einstein Coll Med, Dept Epidemiol & Social Med, 1300 Morris Pk Ave, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein CollMed 1300 Morris Pk Ave Bronx NY USA 10461
Citazione:
J. Fang et al., "Pulse pressure: A predictor of cardiovascular mortality among young normotensive subjects", BLOOD PRESS, 9(5), 2000, pp. 260-266

Abstract

Wide pulse pressure has been associated with increased cardiovascular disease events among hypertensive subjects. To test the hypothesis that this association also exists among normotensive subjects, data from the first National Health and Nutritional Examination Survey and the 1992 EpidemiologicalFollow-up Study were analyzed. The study group included 7346 participants,aged 25-74 years, with baseline blood pressure levels <140/90 mmHg and without a history of hypertension. Deaths from cardiovascular disease and all other causes were determined. At entry, mean age and blood pressure level were 43.4 years and 118/76 mmHg. During an average follow-up period of 17.4 years, there were 1443 (19.6%) deaths, 557 of them ascribed to cardiovascular disease. Age-race-adjusted cardiovascular mortality was significantly higher for those in the highest quartile of pulse pressure (<greater than or equal to>50 mmHg). However, after stratification into age <55 years and <greater than or equal to>55 years, and controlling for other cardiovascular risk factors, increased pulse pressure was associated with cardiovascular mortality only in younger men and women. In these subjects, men and women with pulse pressures greater than or equal to 48, and greater than or equal to46 mmHg, respectively, had a relative risk (95% confidence in terval) of 2.35 (1.21-4.38) and 2.90 (1.34-4.98) for cardiovascular mortality with those with pulse pressures of less than 36 and 34 mmHg, respectively (p < 0.05)as reference. While systolic blood pressure by itself was a weaker predictor of cardiovascular mortality than pulse pressure, diastolic and mean arterial pressure were not predictive at all. No measure of blood pressure was related to mortality in those aged <greater than or equal to>55 years. In conclusion, among young subjects, but not older normotensive persons, at very low risk of cardiovascular disease, a wide pulse pressure is associated with increased cardiovascular mortality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:37:14