Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cognitive functioning, cortisol release, and symptom severity in patients with schizophrenia
Autore:
Walder, DJ; Walker, EF; Lewine, RJ;
Indirizzi:
Emory Univ, Dept Psychol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA30322 Univ, Dept Psychol, Atlanta, GA 30322 USA Emory Univ, Dept Psychiat, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 niv, Dept Psychiat, Atlanta, GA 30322 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 12, volume: 48, anno: 2000,
pagine: 1121 - 1132
SICI:
0006-3223(200012)48:12<1121:CFCRAS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOZYGOTIC TWINS DISCORDANT; FIRST-EPISODE SCHIZOPHRENIA; DEXAMETHASONE SUPPRESSION TEST; TEMPORAL-LOBE; SALIVARY CORTISOL; HIPPOCAMPAL VOLUME; DECLARATIVE MEMORY; PSYCHOTIC-PATIENTS; BRAIN MORPHOLOGY; BASAL GANGLIA;
Keywords:
cortisol; hippocampus; memory; cognitive; symptoms; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Walder, DJ Emory Univ, Dept Psychol, 532 N Kilgo Circle, Atlanta, GA 30322USA Emory Univ 532 N Kilgo Circle Atlanta GA USA 30322 GA 30322 USA
Citazione:
D.J. Walder et al., "Cognitive functioning, cortisol release, and symptom severity in patients with schizophrenia", BIOL PSYCHI, 48(12), 2000, pp. 1121-1132

Abstract

7Background: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders. Research also suggests that cortisol secretionaugments dopaminergic activity, which may result in increased symptom expression in this clinical population. Methods: We examined the relations among cortisol release, cognitive performance, and psychotic symptomatology. Subjects were 18 adults with schizophrenia or schizoaffective disorder, seven with a nonpsychotic psychiatric disorder, and 15 normal control subjects. Tests of memory and executive function were administered Cortisol was assayed from multiple saliva samples. Results: Findings indicated the following: I)patients with psychotic disorders scored below the comparison groups on rite cognitive measures; 2) for the entire sample, cortisol levels were inversely correlated with performance on memory and frontal tasks; and 3) among patients, cortisol levels werepositively correlated with ratings of positive, disorganized, and overall symptom severity, but not with negative symptoms. Conclusions: The present results suggest that abnormalities in the hypothalamic-pituitary-adrenal axis and hippocampal systems play a role in observed cognitive deficits across populations. Among psychotic patients, elevatedcortisol secretion is linked with greater symptom severity. (C) 2000 Society of Biological psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 06:20:27