Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of alcohol on the major steps of reverse cholesterol transport
Autore:
Serdyuk, AP; Metelskaya, VA; Ozerova, IN; Kovaltchouk, NV; Olferiev, AM; Bubnova, MG; Perova, NV; Jauhiainen, M; Lasselin, C; Castro, G;
Indirizzi:
Natl Res Ctr Prevent Med, Moscow 101953, Russia Natl Res Ctr Prevent Med Moscow Russia 101953 Med, Moscow 101953, Russia Natl Publ Hlth Inst, Dept Biochem, FIN-00300 Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland FIN-00300 N-00300 Helsinki, Finland Inst Pasteur, INSERM, F-59019 Lille, France Inst Pasteur Lille France F-59019 Pasteur, INSERM, F-59019 Lille, France
Titolo Testata:
BIOCHEMISTRY-MOSCOW
fascicolo: 11, volume: 65, anno: 2000,
pagine: 1310 - 1315
SICI:
0006-2979(200011)65:11<1310:EOAOTM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; ESTER TRANSFER PROTEIN; A-II; PLASMA; SERUM; HDL; PARTICLES; ACYLTRANSFERASE; SUBFRACTIONS; METABOLISM;
Keywords:
cholesterol; high density lipoprotein; lecithin : cholesterol acyltransferase; cholesteryl ester transfer protein; reverse cholesterol transport; alcohol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Serdyuk, AP Natl Res Ctr Prevent Med, Petroverigsky Pereulok 10, Moscow 101953, Russia Natl Res Ctr Prevent Med Petroverigsky Pereulok 10 Moscow Russia 101953
Citazione:
A.P. Serdyuk et al., "Effects of alcohol on the major steps of reverse cholesterol transport", BIOCHEM-MOS, 65(11), 2000, pp. 1310-1315

Abstract

The effects of moderate alcohol consumption on the capacity of blood sera to promote acceptance of cholesterol (C) from Fu5AH hepatoma cells, esterification of delivered free C, and transfer of produced cholesteryl esters toapolipoprotein (apo) B-containing lipoproteins have been studied. Twenty male subjects with relatively high (greater than or equal to 50 mg/dl, n = 10) and low (<50 mg/dl, n = 10) high density lipoprotein (HDL) C levels consumed for eight weeks red grape wine (0.3 g ethanol/kg body mass per day). Alcohol consumption reduced total C and low density lipoprotein C levels in both groups of subjects. Low HDL C subjects showed an increase in HDL C, apo AI, apo AII, and lipoprotein (Lp) AI particle levels after alcohol consumption. Alcohol did not affect free C efflux from the cells. However, after the following period of substitution of alcohol with an isocaloric amount of red grape juice, cellular C efflux markedly reduced. While lecithin:cholesterol acyltransferase (LCAT) activity increased during alcohol consumptiononly in subjects with low HDL C, high HDL C subjects showed a significant decrease in cholesteryl eater transfer protein (CETP) activity. At the sametime, alcohol consumption reduced the endogenous C esterification rate andincreased the transfer of endogenous cholesteryl eaters to apo B-containing lipoproteins in both groups. Thus, alcohol consumption in moderate doses enhanced the anti-atherogenicity of the serum lipoprotein spectrum, supporting more effective C efflux from peripheral cells and transport of acceptedC to apo B-containing lipoproteins. The effects of alcohol on the reverse cholesterol transport depend on the initial HDL C level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:10:21