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Titolo:
A peripheral mechanism of fever: differential sensitivity to the antipyretic action of methyl scopolamine
Autore:
Rowsey, PJ; Gordon, CJ;
Indirizzi:
Univ N Carolina, Sch Nursing, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 rsing, Chapel Hill, NC 27599 USA US EPA, Natl Hlth & Environm Effects Res Lab, Div Neurotoxicol, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 oxicol, Res Triangle Pk, NC 27711 USA
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-3, volume: 85, anno: 2000,
pagine: 148 - 155
SICI:
1566-0702(200012)85:1-3<148:APMOFD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBDIAPHRAGMATIC VAGOTOMY; STRESS HYPERTHERMIA; BODY-TEMPERATURE; CHLORPYRIFOS; CYTOKINES; DRUGS; RAT; INTERLEUKIN-6; PHYSOSTIGMINE; HYPOTHERMIA;
Keywords:
body temperature; fever; chlorpyrifos; circadian rhythm; handling; stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Rowsey, PJ Univ N Carolina, Sch Nursing, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 el Hill, NC 27599 USA
Citazione:
P.J. Rowsey e C.J. Gordon, "A peripheral mechanism of fever: differential sensitivity to the antipyretic action of methyl scopolamine", AUTON NEURO, 85(1-3), 2000, pp. 148-155

Abstract

The organophosphate pesticide (OP) chlorpyrifos leads to an acute period of hypothermia followed by a delayed fever in the rat. Methyl scopolamine, aperipheral muscarinic antagonist, is thought to have little effect on bodytemperature of the rat because it does not cross the blood brain barrier. However, administration of methyl scopolamine (1 mg/kg, i.p.) during the period of chlorpyrifos-induced fever results in a rapid recovery of core temperature. This indicates a peripheral cholinergic pathway is operative in the febrile response to chlorpyrifos and possibly other modes of fever. In this study, we evaluated the possible antipyretic role of methyl scopolamine (i.p.) to a variety of stimuli that lead to fever-like responses in the rat: stress-induced (handling and cage switch), chlorpyrifos-induced (15 mg/kg, p.o.), nocturnal-induced, and Lipopolysaccharide (LPS)-induced fever (50 mug/kg, i.p.). Methyl scopolamine led to marked reversal in the elevated core temperature caused by handling, cage switch, and during the nocturnal phase. It is of interest to note that all these elevations of core body temperature are prostaglandin mediated and are blocked with the antipyretic drug, sodium salicylate. However, LPS-induced fever, also a prostaglandin dependent fever, was unaffected by methyl scopolamine. Methyl scopolamine also lowered baseline core temperature when administered during the afternoon, but not during the morning in unstressed animals. It is proposed that a peripheral cholinergic pathway, possibly mediated through afferent vagal pathways, is operative in controlling core temperature during fevers associated with stress, nocturnal phase, and a pesticide. During recovery from exposure to a LPS, the fever appears to be mediated independently of peripheral cholinergic activation. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 07:11:24