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Titolo:
Nociceptin inhibits capsaicin-sensitive contraction to mesenteric nerve stimulation in the guinea-pig isolated ileum
Autore:
Sugimori, S; Kadowaki, M; Yoneda, S; Yamanouchi, M; Nakano, H; Takaki, M;
Indirizzi:
Nara Med Univ, Dept Physiol 2, Nara 6348521, Japan Nara Med Univ Nara Japan 6348521 iv, Dept Physiol 2, Nara 6348521, Japan Nara Med Univ, Dept Surg 1, Nara 6348521, Japan Nara Med Univ Nara Japan6348521 Univ, Dept Surg 1, Nara 6348521, Japan
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 86, anno: 2000,
pagine: 65 - 69
SICI:
1566-0702(200012)86:1-2<65:NICCTM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREJUNCTIONAL MODULATORY ACTION; SENSORY NERVES; ORPHANIN-FQ; PERIPHERAL TERMINALS; CHOLINERGIC CONTRACTIONS; ANTIDROMIC ACTIVATION; MYENTERIC NEURONS; EFFERENT FUNCTION; NEUROPEPTIDE-Y; OPIOID DRUGS;
Keywords:
capsaicin; ileum; mesenteric nerve stimulation; methionine-enkephalin; naloxone; nociceptin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Takaki, M Nara Med Univ, Dept Physiol 2, 840 Shijo Cho, Nara 6348521, Japan Nara Med Univ 840 Shijo Cho Nara Japan 6348521 a 6348521, Japan
Citazione:
S. Sugimori et al., "Nociceptin inhibits capsaicin-sensitive contraction to mesenteric nerve stimulation in the guinea-pig isolated ileum", AUTON NEURO, 86(1-2), 2000, pp. 65-69

Abstract

Mesenteric nerve stimulation (MNS) in the presence of guanethidine and hexamethonium antidromically stimulated extrinsic sensory nerve fibers and cholinergic myenteric motor neurons, resulting in longitudinal muscle contraction in the isolated guinea-pig ileum. Nociceptin (NC) is a recently discovered neuropeptide that structurally resembles an opioid peptide. The aim of the current study was to examine how NC affects the contractile responses to MNS in the isolated guinea-pig ileum, in comparison with an opiate, methionine-enkephalin. These contractions were auxotonically recorded and their amplitude was analyzed. NC (1-100 nM) and methionine-enkephalin (0.1-10 muM) concentration-dependently inhibited the response to MNS (20 Hz, 0.5 ms, supramaximal currents). Naloxone (10 muM) significantly diminished the inhibitory effect of methionine-enkephalin (0.1-10 muM), but did not antagonize the inhibitory effect of NC (1-100 nM). We conclude that NC receptors. distinct from opioid receptors. exist on the capsaicin-sensitive sensory nerve fibers and/or myenteric cholinergic motor neurons in the guinea-pig ileum and that specific antagonists for these NC receptors are not found yet. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 12:56:28