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Titolo:
Antibody responses to respiratory coronavirus infections of cattle during shipping fever pathogenesis
Autore:
Lin, XQ; OReilly, KL; Storz, J; Purdy, CW; Loan, RW;
Indirizzi:
Louisiana State Univ, Sch Vet Med, Dept Vet Microbiol & Parasitol, Baton Rouge, LA 70803 USA Louisiana State Univ Baton Rouge LA USA 70803 , Baton Rouge, LA 70803 USA USDA ARS, Conservat & Prod Res Lab, Bushland, TX 79012 USA USDA ARS Bushland TX USA 79012 vat & Prod Res Lab, Bushland, TX 79012 USA Texas A&M Univ, Dept Vet Pathobiol, College Stn, TX USA Texas A&M Univ College Stn TX USA ept Vet Pathobiol, College Stn, TX USA
Titolo Testata:
ARCHIVES OF VIROLOGY
fascicolo: 11, volume: 145, anno: 2000,
pagine: 2335 - 2349
SICI:
0304-8608(2000)145:11<2335:ARTRCI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BOVINE CORONAVIRUS; STRUCTURAL PROTEINS; DISEASE; SERUM; IMMUNOGLOBULINS; NEUTROPHILS; COMPLEMENT; EXPRESSION; CALVES; GENOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Storz, J Louisiana State Univ, Sch Vet Med, Dept Vet Microbiol & Parasitol, Baton Rouge, LA 70803 USA Louisiana State Univ Baton Rouge LA USA 70803 ouge, LA 70803 USA
Citazione:
X.Q. Lin et al., "Antibody responses to respiratory coronavirus infections of cattle during shipping fever pathogenesis", ARCH VIROL, 145(11), 2000, pp. 2335-2349

Abstract

Antibody responses against respiratory bovine coronavirus (RBCV) infections were monitored in cattle from the onset of a naturally occurring severe skipping fever (SF) epizootic to complete recovery of affected cattle or fatal outcomes. The infection with RE CV was detected in nasal secretions of 86 cattle, and 81 of them developed acute respiratory tract disease, including fatal pneumonia. Cattle nasally shedding RBCV at the beginning of the epizootic experienced characteristic primary immune responses with specific antibodies for hemagglutinin-esterase (HE) and spike (S) glycoproteins. Virus shedding in nasal secretions of the majority of the cattle ceased betweendays 7 and 14 with the appearance of HE- and S-specific antibodies. Nasal samples and lung tissues from 9 of the 10 fatal cases had high titers of RBCV, but these cattle had only IgM responses to RBCV infections. Cattle remaining negative in RBCV isolation tests entered this epizootic with antibodies against HE and S. Protection against respiratory tract disease was apparently associated with high level of opsonic and virus-neutralizing IgG2. The HE and S glycoproteins were recognized earliest by the bovine immune system while the N protein induced antibody responses during the later stage ofinitial infection and the early stage of reinfection. The membrane (M) glycoprotein was the least immunogenic of the major viral structural proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:34:21