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Titolo:
Low-resolution data analysis for low-density lipoprotein particle
Autore:
Lunin, VY; Lunina, NL; Ritter, S; Frey, I; Berg, A; Diederichs, K; Podjarny, AD; Urzhumtsev, A; Baumstark, MW;
Indirizzi:
Univ Nancy 1, Fac Sci, UPRESA CNRS 7036, F-54506 Vandoeuvre Nancy, France Univ Nancy 1 Vandoeuvre Nancy France F-54506 06 Vandoeuvre Nancy, France Russian Acad Sci, Inst Math Problems Biol, Pushchino 142292, Moscow Region, Russia Russian Acad Sci Pushchino Moscow Region Russia 142292 cow Region, Russia Univ Freiburg, Med Klin, D-79106 Freiburg, Germany Univ Freiburg Freiburg Germany D-79106 d Klin, D-79106 Freiburg, Germany Univ Constance, Fak Biol, D-78457 Constance, Germany Univ Constance Constance Germany D-78457 iol, D-78457 Constance, Germany IGBMC, UPR Biol Struct, F-67404 Illkirch, CU Strasbourg, France IGBMC Illkirch CU Strasbourg France F-67404 lkirch, CU Strasbourg, France
Titolo Testata:
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
, volume: 57, anno: 2001,
parte:, 1
pagine: 108 - 121
SICI:
0907-4449(200101)57:<108:LDAFLL>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERY-LOW RESOLUTION; SMALL-ANGLE SCATTERING; MAP CORRELATION-COEFFICIENT; HUMAN APOLIPOPROTEIN-B; AB-INITIO SOLUTION; DIFFRACTION DATA; PHASE PROBLEM; HUMAN-PLASMA; MACROMOLECULAR CRYSTALLOGRAPHY; IMMUNOELECTRON MICROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Lunin, VY Univ Nancy 1, Fac Sci, UPRESA CNRS 7036, LCM3B, F-54506 Vandoeuvre Nancy, France Univ Nancy 1 LCM3B Vandoeuvre Nancy France F-54506 ancy, France
Citazione:
V.Y. Lunin et al., "Low-resolution data analysis for low-density lipoprotein particle", ACT CRYST D, 57, 2001, pp. 108-121

Abstract

The knowledge of the molecular structure of LDL, a large lipoprotein complex, is of great interest for medical investigations. Currently available LDL crystals do not diffract to high resolution and do not allow the application of standard crystallographic techniques. Additional difficulties arise because of a very dense crystal packing and the presence of several components with quite different mean densities. Several ab initio phasing methods previously reported by the authors have been successfully applied to rnd a crystallographic image of LDL at a resolution of 27 Angstrom. The most promising results have been obtained using direct phasing with a connectivity analysis of the electron-density maps. The current image makes it possible to discern a single particle covered by a layer of relatively high density that is asymmetrically distributed on the particle surface. It shows a partition of high and low densities inside the particle and, in particular, strips of varying density in the lipid core.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 11:23:01