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Titolo:
Immunogenicity and safety of monovalent P1.7(h),4 meningococcal outer membrane vesicle vaccine in toddlers: comparison of two vaccination schedules and two vaccine formulations
Autore:
de Kleijn, ED; de Groot, R; Lafeber, AB; Labadie, J; van Limpt, KCJP; Visser, J; Berbers, GAM; van Alphen, L; Rumke, HC;
Indirizzi:
Univ Rotterdam Hosp, Sophia Childrens Hosp, Dept Pediat, NL-3015 GJ Rotterdam, Netherlands Univ Rotterdam Hosp Rotterdam Netherlands NL-3015 GJ terdam, Netherlands Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands Natl Inst Publ Hlth & Environm Bilthoven Netherlands NL-3720 BA herlands
Titolo Testata:
VACCINE
fascicolo: 9-10, volume: 19, anno: 2000,
pagine: 1141 - 1148
SICI:
0264-410X(200012)19:9-10<1141:IASOMP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEISSERIA-MENINGITIDIS; IMMUNE-RESPONSE; PROTEIN VACCINE; DISEASE; ANTIBODIES; EFFICACY; PORA; CONSTRUCTION; SPECIFICITY; CHILDREN;
Keywords:
Neisseria meningitidis; outer membrane vesicle vaccine; children;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: de Groot, R Univ Rotterdam Hosp, Sophia Childrens Hosp, Dept Pediat, Dr Molewaterpl 60, NL-3015 GJ Rotterdam, Netherlands Univ Rotterdam Hosp Dr Molewaterpl 60 Rotterdam Netherlands NL-3015 GJ
Citazione:
E.D. de Kleijn et al., "Immunogenicity and safety of monovalent P1.7(h),4 meningococcal outer membrane vesicle vaccine in toddlers: comparison of two vaccination schedules and two vaccine formulations", VACCINE, 19(9-10), 2000, pp. 1141-1148

Abstract

The safety and immunogenicity of two PorA-based meningococcal outer membrane vesicle (OMV) vaccines against the P1.4 serosubtype adsorbed with AlPO4 or Al(OH)(3) were studied in 134 toddlers. Vaccinations were given three times with an interval of 3-6 weeks or twice with an interval of 6-10 weeks. A vaccination was repeated after 20-40 weeks. Pre- and post-immunization sera were tested for bactericidal activity against an isogenic strain expressing P1.7(h),4 PorA. Both meningococcal OMV vaccines were well tolerated. The percentage of children with a fourfold increase in bactericidal activity was 96% (AlPO4-adjuvated vaccine/2 + 1 schedule), 100% (AlPO4-adjuvated vaccine/3 + 1, schedule), 93% (Al(OH)(3)-adjuvated vaccine/2 + 1 schedule) and97% (Al(OH)(3)-adjuvated vaccine/3 + 1 schedule). Adsorption with AlPO4 makes the OMV vaccine more immunogenic than adsorption with AI(OH)(3). Bactericidal activity was highest after the 3 + 1 schedule, although the responseshortly after the primary series was higher in the two-dose priming group. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:39:37