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Titolo:
Reduced antibody response to revaccination with meningococcal serogroup A polysaccharide vaccine in adults
Autore:
Borrow, R; Joseph, H; Andrews, N; Acuna, M; Longworth, E; Martin, S; Peake, N; Rahim, R; Richmond, P; Kaczmarski, E; Miller, E;
Indirizzi:
Withington Hosp, Publ Hlth Lab, Meningococcal Ref Unit, Manchester M20 2LR, Lancs, England Withington Hosp Manchester Lancs England M20 2LR M20 2LR, Lancs, England PHLS, Stat Unit, London NW9 5DF, England PHLS London England NW9 5DFPHLS, Stat Unit, London NW9 5DF, England Publ Hlth Lab Serv, Ctr Communicable Dis Surveillance, Immunisat Div, London NW9 5EQ, England Publ Hlth Lab Serv London England NW9 5EQ t Div, London NW9 5EQ, England
Titolo Testata:
VACCINE
fascicolo: 9-10, volume: 19, anno: 2000,
pagine: 1129 - 1132
SICI:
0264-410X(200012)19:9-10<1129:RARTRW>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROUP-A; CONJUGATE VACCINE; IMMUNOLOGICAL MEMORY; GAMBIAN CHILDREN; IMMUNIZATION; INFANTS; INDUCTION; KINETICS;
Keywords:
meningococcal serogroup A; vaccine; hyporesponsiveness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Borrow, R Withington Hosp, Publ Hlth Lab, Meningococcal Ref Unit, Nell Lane,W Didsbury, Manchester M20 2LR, Lancs, England Withington Hosp Nell Lane,W Didsbury Manchester Lancs England M20 2LR
Citazione:
R. Borrow et al., "Reduced antibody response to revaccination with meningococcal serogroup A polysaccharide vaccine in adults", VACCINE, 19(9-10), 2000, pp. 1129-1132

Abstract

Widespread use of meningococcal A and C polysaccharide (MACP) vaccines hasraised concerns about induction of hyporesponsiveness to these polysaccharides. Immunological hyporesponsiveness to C polysaccharide has been clearlydocumented in infants, children and adults but only limited data from Gambian children are available for A polysaccharide. We investigated whether a second dose of MACP, given 6 months after an initial dose affected the immunological response as measured by the serum bactericidal assay (SBA) and enzyme-linked immunosorbent assay (ELISA), to serogroup A meningococci in young adults (university students, n = 36). Serogroup A SEA responses 1 month following the second dose of MACP (geometric mean titre (GMT) 103.6, 95% CI45.6-235.1) were approximately one third of the levels observed 1 month post first dose (GMT 281.9, 95% CI 134.9-581.4). The serogroup A-specific IgGlevels post second dose (GMC 21.2, 95% CI 15.3-29.4) were also significantly lower at an average of three-quarters the level post first dose (GMC 28.7, 95% CI 20.8-39.7). This confirms that revaccination with MACP vaccine, 6months following the initial dose, results in a reduced immunological response to A polysaccharide in adults. Repeated vaccination with MACP vaccine may be ineffective and development and use of meningococcal serogroup A conjugate vaccines should be encouraged. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 00:15:10