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Titolo:
Phthalic acid mimics 17 beta-estradiol actions in WISH cells
Autore:
Pavan, B; Biondi, C; Ferretti, ME; Lunghi, L; Paganetto, G;
Indirizzi:
Univ Ferrara, Dept Biol, Sect Gen Physiol, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 t Gen Physiol, I-44100 Ferrara, Italy Montell Italia, Ctr Ric G Natta, I-44100 Ferrara, Italy Montell Italia Ferrara Italy I-44100 Ric G Natta, I-44100 Ferrara, Italy
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 3, volume: 118, anno: 2001,
pagine: 157 - 164
SICI:
0378-4274(20010103)118:3<157:PAM1BA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR; PROGESTERONE-RECEPTOR; BREAST-CANCER; ESTROGEN; INDUCTION; PROSTAGLANDINS; PREGNANCY; ESTERS; RATS; LINE;
Keywords:
WISH cells; phthalic acid; 17 beta-estradiol receptors; prostaglandin release; cyclic AMP system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Ferretti, ME Univ Ferrara, Dept Biol, Sect Gen Physiol, Via Luigi Borsari 46, I-44100 Ferrara, Italy Univ Ferrara Via Luigi Borsari 46 Ferrara ItalyI-44100 taly
Citazione:
B. Pavan et al., "Phthalic acid mimics 17 beta-estradiol actions in WISH cells", TOX LETT, 118(3), 2001, pp. 157-164

Abstract

The object of this study was to evaluate whether phthalic acid, which is one of the metabolites of phthalic acid esters, exerts estrogenic actions inWISH cells, an immortalized cell line derived from human amniotic tissue. Our data demonstrate that phthalic acid (i) displaces [H-3]estradiol from its binding sites, (ii) enhances the intracellular cyclic AMP concentration,without influencing adenylyl cyclase activity, (iii) stimulates or inhibits prostaglandin output, probably depending on the intracellular nucleotide level. The effects on prostanoid release are counteracted by addition of the protein-synthesis inhibitor cycloheximide, or when the diffusion of phthalic acid through the cell membrane is prevented. On the basis of our previous demonstration, that 17 beta -estradiol exerts similar effects in WISH cells, we suggest that the molecular mechanisms underlying phthalic acid and steroid-hormone responses in this cell line are the same. This is the firstdemonstration that phthalic acid binds to the estrogen receptor with high affinity and mimics the hormone physiological actions. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 13:49:42