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Titolo:
Supporting evidence for the model of cognitive dysmetria in schizophrenia - a structural magnetic resonance imaging study using deformation-based morphometry
Autore:
Volz, HP; Gaser, C; Sauer, H;
Indirizzi:
Univ Jena, Dept Psychiat, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 ena, Dept Psychiat, D-07740 Jena, Germany
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1, volume: 46, anno: 2000,
pagine: 45 - 56
SICI:
0920-9964(20001130)46:1<45:SEFTMO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDHOOD-ONSET SCHIZOPHRENIA; SUPERIOR TEMPORAL GYRUS; GRAY-MATTER VOLUME; CEREBELLAR CIRCUITRY; TARDIVE-DYSKINESIA; MEDICATED PATIENTS; THOUGHT-DISORDER; BASAL GANGLIA; 4TH VENTRICLE; BRAIN;
Keywords:
brain structure; MRI; schizophrenia; whole-brain analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Volz, HP Univ Jena, Dept Psychiat, Philosophenweg 3, D-07740 Jena, GermanyUniv Jena Philosophenweg 3 Jena Germany D-07740 40 Jena, Germany
Citazione:
H.P. Volz et al., "Supporting evidence for the model of cognitive dysmetria in schizophrenia - a structural magnetic resonance imaging study using deformation-based morphometry", SCHIZOPHR R, 46(1), 2000, pp. 45-56

Abstract

The aim of the study was to investigate whether there is any structural evidence for the model of 'cognitive dysmetria' in schizophrenia if an automatic whole-brain analysis method is used. High-resolution magnetic resonancescans were obtained for 75 schizophrenic patients and 75 controls. These data were analysed using the recently developed deformation-based morphometry allowing the assessment of volumetric differences without a priori definition of regions of interest. When compared with controls, we found reduced volumes in patients with schizophrenia in the frontal lobe (gyrus frontalissuperior, medius and medialis), the temporal lobe (gyrus temporalis superior and inferior), the thalamus, the left cerebellar hemisphere and the right cerebellar vermis. There was an increase in volume in the right putamen. To date, this is the first structural magnetic resonance Imaging study to demonstrate that the three key-elements of the model of cognitive dysmetria - frontal lobe, thalamus, and cerebellum - are reduced in volume in schizophrenic patients. This highlights the importance of this concept for future investigations. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:42:10