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Titolo:
The HTR1B 861G > C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy
Autore:
Fehr, C; Grintschuk, N; Szegedi, A; Anghelescu, I; Klawe, C; Singer, P; Hiemke, C; Dahmen, N;
Indirizzi:
Univ Mainz, Dept Psychiat, D-55101 Mainz, Germany Univ Mainz Mainz Germany D-55101 , Dept Psychiat, D-55101 Mainz, Germany
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 1, volume: 97, anno: 2000,
pagine: 1 - 10
SICI:
0165-1781(200012)97:1<1:TH8>CR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEST-RETEST RELIABILITY; MICE LACKING; 5-HT1B RECEPTOR; KNOCKOUT MICE; SEROTONIN; CONSUMPTION; 5-HT1D-BETA; INTERVIEW; GENETICS; BEHAVIOR;
Keywords:
psychiatric genetics; alcoholism genetics; serotonin; HTR1B; association study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Fehr, C Oregon Hlth Sci Univ, Dept Behav Neurosci, Portland Alcohol Res Ctr, 3710 US Vet Hosp Rd, Portland, OR 97201 USA Oregon Hlth Sci Univ 3710 USVet Hosp Rd Portland OR USA 97201 USA
Citazione:
C. Fehr et al., "The HTR1B 861G > C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy", PSYCHIAT R, 97(1), 2000, pp. 1-10

Abstract

The HTR1B receptor gene has been linked to antisocial alcoholism in a Finnish population and an American Indian tribe [Lappalainen et al., Arch. Gen. Psychiatry, 55 (1998) 989]. Using a candidate gene approach, we genotyped 209 patients with alcoholism, 108 patients with major depression, 32 patients with panic disorder, 50 patients with generalized anxiety disorder, 58 patients with narcolepsy and 74 healthy volunteers for the HTR1B 861G > C polymorphism. There was a higher frequency of the HTR1B 861G alleles among the alcohol-dependent patients as compared to the control subjects (chi (2) =4.02, d.f. = 2, P = 0.04). However, the association resulted from higher frequencies of the opposite alleles (HTR1B 861G), as originally reported by Lappalainen et al. (1998). Although the association in our study might be due to a type I error, the higher degree of HTR1B allele sharing within bothpopulations could also argue for another alcoholism-relevant gene within the proximity of the HTR1B gene on human chromosome 6. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 19/01/20 alle ore 14:52:23