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Titolo:
New method for accurate prediction of solvent accessibility from protein sequence
Autore:
Li, X; Pan, XM;
Indirizzi:
Acad Sinica, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples RChina Acad Sinica Beijing Peoples R China 100101 eijing 100101, Peoples RChina
Titolo Testata:
PROTEINS-STRUCTURE FUNCTION AND GENETICS
fascicolo: 1, volume: 42, anno: 2001,
pagine: 1 - 5
SICI:
0887-3585(20010101)42:1<1:NMFAPO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SECONDARY STRUCTURE PREDICTION; ENVIRONMENT; PRINCIPLES; EXPOSURE; CHAINS;
Keywords:
protein structure prediction; solvent accessibility; multiple linear regression; chain length effect;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Pan, XM Acad Sinica, Inst Biophys, Natl Lab Biomacromol, 15 Datun Rd, Beijing 100101, Peoples R China Acad Sinica 15 Datun Rd Beijing Peoples R China 100101 es R China
Citazione:
X. Li e X.M. Pan, "New method for accurate prediction of solvent accessibility from protein sequence", PROTEINS, 42(1), 2001, pp. 1-5

Abstract

A novel method was developed for predicting the solvent accessibility. Based on single sequence data, this method achieved 71.5% accuracy with a correlation coefficient of 0.42 in a database of 704 proteins with threshold of20% for a two-state-defining solvent accessibility. Prediction in a data subset of 341 monomeric proteins achieved 72.7% accuracy with a correlation coefficient of 0.43. On the average, prediction over short chains gives better results than that over long chains. With a solvent accessibility threshold of 20%, prediction over 236 monomeric proteins with chain length < 300 amino acid residues achieved 75.3% accuracy with a correlation coefficient of 0.44 by jackknife analysis, which is higher than that obtained by previous methods using multiple sequence alignments. Proteins 2001;42:1-5. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:02:36