Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Structural organization of yeast and mammalian mediator complexes
Autore:
Dotson, MR; Yuan, CX; Roeder, RG; Myers, LC; Gustafsson, CM; Jiang, YW; Li, Y; Kornberg, RD; Asturias, FJ;
Indirizzi:
Scripps Clin & Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 iol, La Jolla, CA 92037 USA Rockefeller Univ, Biochem & Mol Biol Lab, New York, NY 10021 USA Rockefeller Univ New York NY USA 10021 l Biol Lab, New York, NY 10021 USA Stanford Univ, Sch Med, Dept Biol Struct, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 t Biol Struct, Stanford, CA 94305 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 26, volume: 97, anno: 2000,
pagine: 14307 - 14310
SICI:
0027-8424(200012)97:26<14307:SOOYAM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA-POLYMERASE-II; TRANSCRIPTIONAL ACTIVATION; NUCLEAR RECEPTORS; BINDING PROTEIN; REPEAT DOMAIN; HOLOENZYME; RECONSTRUCTION; COMPONENTS; MUTATIONS; PATHWAYS;
Keywords:
RNA polymerase II holoenzyme; transcriptional regulation; TRAP; electron microscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Asturias, FJ Scripps Clin & Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 , CA 92037 USA
Citazione:
M.R. Dotson et al., "Structural organization of yeast and mammalian mediator complexes", P NAS US, 97(26), 2000, pp. 14307-14310

Abstract

Structures of yeast Mediator complex, of a related complex from mouse cells and of thyroid hormone receptor-associated protein complex from human cells have been determined by three-dimensional reconstruction from electron micrographs of single particles. AII three complexes show a division in two parts, a "head" domain and a combined "middle-tail" domain. The head domains of the three complexes appear most similar and interact most closely withRNA polymerase II. The middle-tail domains show the greatest structural divergence and, in the case of the tail domain, may not interact with polymerase at ail. Consistent with this structural divergence, analysis of a yeastMediator mutant localizes subunits that are not conserved between yeast and mammalian cells to the tail domain. Biochemically defined Rgr1 and Srb4 modules of yeast Mediator are then assigned to the middle and head domains.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 16:21:47