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Titolo:
Allelic complementation between MHC haplotypes B-Q and B-17 increases regression of Rous sarcomas
Autore:
Senseney, HL; Briles, WE; Abplanalp, H; Taylor, RL;
Indirizzi:
Univ New Hampshire, Dept Anim & Nutr Sci, Durham, NH 03824 USA Univ New Hampshire Durham NH USA 03824 m & Nutr Sci, Durham, NH 03824 USA No Illinois Univ, Dept Biol Sci, De Kalb, IL 60115 USA No Illinois Univ De Kalb IL USA 60115 ept Biol Sci, De Kalb, IL 60115 USA Univ Calif Davis, Dept Anim Sci, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 s, Dept Anim Sci, Davis, CA 95616 USA
Titolo Testata:
POULTRY SCIENCE
fascicolo: 12, volume: 79, anno: 2000,
pagine: 1736 - 1740
SICI:
0032-5791(200012)79:12<1736:ACBMHB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RSV-INDUCED TUMORS; HISTOCOMPATIBILITY (B)-COMPLEX CONTROL; V-SRC; CONGENIC LINES; INBRED LINES; CHICKEN MHC; LOCUS MHC; COMPLEX; RESISTANCE; IMMUNITY;
Keywords:
major histocompatibility (B) complex; Rous sarcoma virus; oncogene; tumor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, RL Univ New Hampshire, Dept Anim & Nutr Sci, Durham, NH 03824 USA Univ New Hampshire Durham NH USA 03824 i, Durham, NH 03824 USA
Citazione:
H.L. Senseney et al., "Allelic complementation between MHC haplotypes B-Q and B-17 increases regression of Rous sarcomas", POULTRY SCI, 79(12), 2000, pp. 1736-1740

Abstract

Major histocompatibility (B) complex haplotypes B-Q and B-17 were examinedfor their effect on Rous sarcoma outcome. Pedigree matings of (BB17)-B-Q chickens from the second backcross generation (BC2) of Line UCD 001 ((BBQ)-B-Q) mated to Line UCD 003 ((BB17)-B-17) produced progeny with genotypes (BBQ)-B-Q, (BB17)-B-Q, and (BB17)-B-17. Six-week-old chickens were injected with subgroup A Rous sarcoma virus (RSV). The tumors were scored for size at 2, 3, 4, 6, 8, and 10 weeks postinoculation. A tumor profile index (TPI) was assigned to each bird based on the six tumor scores. Two experiments withtwo trials each were conducted. In Experiment 1, chickens (n = 84) were inoculated with 30 pock-forming units (pfu) RSV. There was no significant B genotype effect on tumor growth over time or TPI among the 70 chickens that developed tumors. Chickens (n = 141) were injected with 15 PFU RSV in Experiment 2. The B genotype significantly affected tumor growth pattern over time in the 79 chickens with sarcomas. The (BB17)-B-Q chickens had the lowestTPI, which was significantly different from (BB17)-B-17 but not (BBQ)-B-Q. The data indicate complementation because more tumor regression occurs in the (BB17)-B-Q heterozygote than in either (BBQ)-B-Q or (BB17)-B-17 genotypes at a 15 pfu RSV dose and significantly so compared to (BB17)-B-17. By contrast, the 30 pfu RSV dose utilized in the first experiment overwhelmed all genotypic combinations of the B-Q and B-17 haplotypes, suggesting that certain MHC genotypes affect the immune response under modest levels of viralchallenge.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:19:35