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Titolo:
Simple models of the protein folding problem
Autore:
Tang, C;
Indirizzi:
NEC Res Inst, Princeton, NJ 08540 USA NEC Res Inst Princeton NJ USA 08540NEC Res Inst, Princeton, NJ 08540 USA
Titolo Testata:
PHYSICA A
fascicolo: 1-4, volume: 288, anno: 2000,
pagine: 31 - 48
SICI:
0378-4371(200012)288:1-4<31:SMOTPF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOM-ENERGY MODEL; STATISTICAL-MECHANICS; DESIGN PROBLEM; SEQUENCES; DESIGNABILITY; COPOLYMERS; STABILITY;
Keywords:
protein folding; lattice models; enumeration; designability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Tang, C NEC Res Inst, 4 Independence Way, Princeton, NJ 08540 USA NEC Res Inst 4 Independence Way Princeton NJ USA 08540 J 08540 USA
Citazione:
C. Tang, "Simple models of the protein folding problem", PHYSICA A, 288(1-4), 2000, pp. 31-48

Abstract

The protein folding problem has attracted an increasing attention from physicists. The problem has a flavor of statistical mechanics, hut possesses the most common feature of most biological problems - the profound effects of evolution. I will give an introduction to the problem, and then focus on some recent work concerning the so-called "designability principle". The designability of a structure is measured by the number of sequences that havethat structure as their unique ground state. Structures differ drasticallyin terms of their designability; highly designable structures emerge with a number of associated sequences much larger than the average. These highlydesignable structures (1) possess "protein-like" secondary structures and motifs, (2) are thermodynamically more stable, (3) fold faster than other structures. These results suggest that protein structures are selected in nature because they are readily designed and stable against mutations, and that such selection simultaneously leads to thermodynamic stability and foldability. According to this picture, a key to the protein folding problem is to understand the emergence and the properties of the highly desginable structures. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/03/20 alle ore 09:20:17