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Titolo:
Animal models of Alzheimer's disease and evaluation of anti-dementia drugs
Autore:
Yamada, K; Nabeshima, T;
Indirizzi:
Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol, Showa Ku, Nagoya, Aichi 4668560, Japan Nagoya Univ Nagoya Aichi Japan 4668560 a Ku, Nagoya, Aichi 4668560, Japan Nagoya Univ, Hosp Pharm, Grad Sch Med, Showa Ku, Nagoya, Aichi 4668560, Japan Nagoya Univ Nagoya Aichi Japan 4668560 a Ku, Nagoya, Aichi 4668560, Japan
Titolo Testata:
PHARMACOLOGY & THERAPEUTICS
fascicolo: 2, volume: 88, anno: 2000,
pagine: 93 - 113
SICI:
0163-7258(200011)88:2<93:AMOADA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; NERVE GROWTH-FACTOR; FOREBRAIN-LESIONED RATS; LONG-TERM POTENTIATION; CORTICAL CHOLINERGIC INNERVATION; HEREDITARY CEREBRAL-HEMORRHAGE; NGF SYNTHESIS STIMULATORS; PAIRED HELICAL FILAMENTS; BETA-PEPTIDE DEPOSITION; WORKING-MEMORY DEFICITS;
Keywords:
Alzheimer's disease; amyloid beta-peptide (A beta); beta-amyloid precursor protein (APP); tau; presenilins; animal model;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
281
Recensione:
Indirizzi per estratti:
Indirizzo: Nabeshima, T Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol, Showa Ku, Nagoya, Aichi 4668560, Japan Nagoya Univ Nagoya Aichi Japan 4668560 Aichi 4668560, Japan
Citazione:
K. Yamada e T. Nabeshima, "Animal models of Alzheimer's disease and evaluation of anti-dementia drugs", PHARM THERA, 88(2), 2000, pp. 93-113

Abstract

Alzheimer's disease (AD) is the most common cause of progressive decline of cognitive function in aged humans, and is characterized by the presence of numerous senile plaques and neurofibrillary tangles accompanied by neuronal loss. Some, but not all, of the neuropathological alterations and cognitive impairment in AD can be reproduced genetically and pharmacologically inanimals. It should be possible to discover novel drugs that slow the progress or alleviate the clinical symptoms of AD by using these animal models. We review the recent progress in the development of animal models of AD anddiscuss how to use these model animals to evaluate novel anti-dementia drugs. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:35:17