Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A long-term high-carbohydrate diet causes an altered ontogeny of pancreatic islets of Langerhans in the neonatal rat
Autore:
Petrik, J; Srinivasan, M; Aalinkeel, R; Coukell, S; Arany, E; Patel, MS; Hill, DJ;
Indirizzi:
St Josephs Hlth Ctr, Lawson Res Inst, London, ON N6A 4V2, Canada St Josephs Hlth Ctr London ON Canada N6A 4V2 , London, ON N6A 4V2, Canada Univ Western Ontario, Dept Physiol, London, ON N6A 5A5, Canada Univ Western Ontario London ON Canada N6A 5A5 London, ON N6A 5A5, Canada Univ Western Ontario, Dept Med, London, ON N6A 5A5, Canada Univ Western Ontario London ON Canada N6A 5A5 London, ON N6A 5A5, Canada Univ Western Ontario, Dept Paediat, London, ON N6A 5A5, Canada Univ Western Ontario London ON Canada N6A 5A5 London, ON N6A 5A5, Canada SUNY Buffalo, Sch Med & Biomed Sci, Dept Biochem, Buffalo, NY 14214 USA SUNY Buffalo Buffalo NY USA 14214 ci, Dept Biochem, Buffalo, NY 14214 USA
Titolo Testata:
PEDIATRIC RESEARCH
fascicolo: 1, volume: 49, anno: 2001,
pagine: 84 - 92
SICI:
0031-3998(200101)49:1<84:ALHDCA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-II; BETA-CELL MASS; HUMAN-FETAL PANCREAS; PREWEANING PERIOD; SURVIVAL FACTOR; APOPTOSIS; EXPRESSION; MODEL; MICE; GASTROSTOMY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Hill, DJ St Josephs Hlth Ctr, Lawson Res Inst, 268 Grosvenor St, London, ON N6A 4V2, Canada St Josephs Hlth Ctr 268 Grosvenor St London ON Canada N6A4V2 ada
Citazione:
J. Petrik et al., "A long-term high-carbohydrate diet causes an altered ontogeny of pancreatic islets of Langerhans in the neonatal rat", PEDIAT RES, 49(1), 2001, pp. 84-92

Abstract

Neonatal rats fed a high-carbohydrate (HC) formula by gastrostomy are hyperinsulinemic but normoglycemic. We determined whether HC formula altered pancreatic islet cell ontogeny. Rats were reared from d 4 on an HC formula ora high-fat formula, or were allowed to suckle naturally, and the pancreatawere examined histologically from animals less than or equal to 24 d of age. The mean area of individual islets was reduced, but islet number was increased in HC rats compared with mother-fed or high fat-fed animals, which were similar. Islets from HC animals were relatively deficient in cu cells and had a greater incidence of islet cells with fragmented DNA, indicative of apoptosis. Ductal epithelium, a source of new islets by neogenesis, had agreater incidence of cells staining immunopositive for proliferating cell nuclear antigen, a marker of cell replication, and a lower incidence of apoptosis. The islet cell mitogen and survival factor, IGF-II, had a reduced mRNA expression in whole pancreas from HC animals. The relative area of islet cells demonstrating IGF-II immunoreactivity was reduced in HC-fed rats versus controls, although a greater percentage of ductal epithelial cells were immunopositive. HC formula alters islet cell ontogeny by affecting islet size and number, which may be linked to an altered IGF-II expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 15:01:11