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Titolo:
Mouse islets cultured with vasoactive intestinal polypeptide: Effects on insulin release and immunoreactivity for tyrosine hydroxylase
Autore:
Persson-Sjogren, S; Forsgren, S; Shi, CL; Taljedal, IB;
Indirizzi:
Umea Univ, Dept Integrat Med Biol, Sect Histol & Cell Biol, SE-90187 Umea,Sweden Umea Univ Umea Sweden SE-90187 Histol & Cell Biol, SE-90187 Umea,Sweden Umea Univ, Dept Integrat Med Biol, Dept Anat, SE-90187 Umea, Sweden Umea Univ Umea Sweden SE-90187 ed Biol, Dept Anat, SE-90187 Umea, Sweden
Titolo Testata:
PANCREAS
fascicolo: 1, volume: 22, anno: 2001,
pagine: 84 - 90
SICI:
0885-3177(200101)22:1<84:MICWVI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; PANCREATIC-ISLETS; NEUROPEPTIDE-Y; ENDOCRINE PANCREAS; KIDNEY CAPSULE; BETA-CELLS; EXPRESSION; LANGERHANS; INDUCTION; GLUCAGON;
Keywords:
beta cells; insulin secretion; islets of Langerhans; mouse; tyrosine hydroxylase; vasoactive intestinal polypeptide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Persson-Sjogren, S Umea Univ, Dept Integrat Med Biol, Sect Histol & Cell Biol, SE-90187 Umea,Sweden Umea Univ Umea Sweden SE-90187 , SE-90187 Umea,Sweden
Citazione:
S. Persson-Sjogren et al., "Mouse islets cultured with vasoactive intestinal polypeptide: Effects on insulin release and immunoreactivity for tyrosine hydroxylase", PANCREAS, 22(1), 2001, pp. 84-90

Abstract

Mouse islets cultured for 1 or 4 days with or without 10 nM vasoactive intestinal polypeptide (VIP) were stained for tyrosine hydroxylase (TH) and examined for insulin secretion during culture and in a postculture perifusionsystem. Exposure to exogenous VIP for 4 days increased the frequency of islet cells expressing TH-like immunoreactivity. Regardless of the culturing conditions, the islets exhibited significant insulin secretory responses to16.7 mM glucose, the effect being potentiated by 10 nM VIP in the perifusion medium. The insulin-releasing action of glucose and the potentiating effect of VIP were less pronounced in islets cultured for 1 day with VIP than in islets cultured without this neuropeptide. The following conclusions aresuggested: (a) VIP stimulates the expression of TH in mouse islet cells; (b) the latency of the VIP-induced TH is a postreceptor phenomenon; (c) islet cultures exposed to VIP represent a new instance of the association between increased functional demands on beta cells and enhanced expression of THand a new instance of VIP having trophic effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:42:25