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Titolo:
Distributional patterns of phospholipase C isozymes in rat pancreas
Autore:
Kim, MJ; Lee, KH; Min, DS; Yoon, SH; Hahn, SJ; Kim, MS; Jo, YH;
Indirizzi:
Catholic Univ Korea, Coll Med, Dept Physiol, Seoul 137701, South Korea Catholic Univ Korea Seoul South Korea 137701 , Seoul 137701, South Korea Catholic Univ Korea, Coll Med, Dept Pharmacol, Seoul 137701, South Korea Catholic Univ Korea Seoul South Korea 137701 , Seoul 137701, South Korea
Titolo Testata:
PANCREAS
fascicolo: 1, volume: 22, anno: 2001,
pagine: 47 - 52
SICI:
0885-3177(200101)22:1<47:DPOPCI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-TRANSDUCTION; MOLECULAR-CLONING; GROWTH-FACTOR; BOVINE BRAIN; ACTIVATION; PURIFICATION; EXPRESSION; INSULIN; GAMMA; LOCALIZATION;
Keywords:
phospholipase C; acinar tissues; islet of Langerhans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Jo, YH Catholic Univ Korea, Coll Med, Dept Physiol, 505 Banpo Dong, Seoul 137701,South Korea Catholic Univ Korea 505 Banpo Dong Seoul South Korea 137701 Korea
Citazione:
M.J. Kim et al., "Distributional patterns of phospholipase C isozymes in rat pancreas", PANCREAS, 22(1), 2001, pp. 47-52

Abstract

Phospholipase C (PLC) isozymes are believed to play a role in regulating pancreatic exocrine and endocrine secretion. in an attempt to investigate the role of PLC, we examined the distribution patterns of PLC isozymes in thenormal rat pancreas by Western blot analysis and immunohistochemistry. Western blot analysis was performed on pancreatic acinar tissues and the isletof Langerhans, which were separated from each other. PLC-beta isozymes (beta1, beta2, beta3, and beta4), delta1, and delta2 were detected in both acinar and islet cells, whereas PLC-gamma1 and gamma2 were observed only in acinar tissues. On immunohistochemistry, the immunoreactivities of PLC isozymes except fur PLC-gamma1 were observed as follows: PLC-beta1, in both the exocrine and endocrine tissues; PLC-beta2, mainly in the periphery of the islet and acinar cells; PLC-beta3, in the periphery of the islet and in some ductal epithelium; PLC-beta4, through the islet of Langerhans and ductal epithelium; PLC-gamma1, not. detected in pancreatic tissue; PLC-gamma2, mainly in acinar cells; PLC-delta1 and delta2, in the islet and in ductal epithelium. These results suggest that the intrapancreatic site-specific existence of PLC isozymes may modulate pancreatic exocrine and endocrine functions through a PLC-mediated signal transduction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:22:12